Evidence map›Paper›PMID 28079136›Full record

Trial reportScientific reports2017

SNP rs11185644 of RXRA gene is identified for dose-response variability to vitamin D3 supplementation: a randomized clinical trial.

Mingzhi Zhang, Lan-Juan Zhao, Yu Zhou, Rhamee Badr, Patrice Watson, An Ye, Boting Zhou, Jigang Zhang, Hong-Wen Deng, Robert R Recker and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Association of free vitamin DAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018
    Trial
  7. Article
  8. Article
  9. Review
  10. The DuckAnimals : an open access journal from MDPI · 2023
    Article
  11. Impact of daily vitamin DFrontiers in nutrition · 2022
    Article
  12. Article
  13. Nutrigenetics-personalized nutrition in obesity and cardiovascular diseases.International journal of obesity supplements · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Mingzhi ZhangSchool of Public Health, Medical College of Soochow University, Department of Epidemiology &Biostatistics, Suzhou, 215123, China.
Lan-Juan ZhaoCenter for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.
Yu ZhouCenter for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.
Rhamee BadrSchool of Medicine, Tulane University, New Orleans, LA, 70112, USA.
Patrice WatsonOsteoporosis Research Center, Creighton University, Omaha, NE, 68131, USA.
An YeCenter for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.
Boting ZhouOsteoporosis Research Center, Creighton University, Omaha, NE, 68131, USA.
Jigang ZhangCenter for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.
Hong-Wen DengCenter for Bioinformatics and Genomics, Department of Biostatistics and Bioinformatics, Tulane University, New Orleans, LA, 70112, USA.
Robert R ReckerOsteoporosis Research Center, Creighton University, Omaha, NE, 68131, USA.
Joan M LappeOsteoporosis Research Center, Creighton University, Omaha, NE, 68131, USA.
Tulane University · USCreighton University · USSoochow University · CN

Funding

Proteome-wide Expression Study of Osteogenic CellsP50AR055081 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2012
$5.0M
Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal WomenR01CA129488 · NCI · CREIGHTON UNIVERSITY · PI LAPPE, JOAN · 2009 to 2013
$4.5M
ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASSR01AR050496 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2004 to 2013
$3.8M
Identification of Proteins Important for Male OsteoporosisR01AR057049 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2009 to 2013
$2.4M
Genomic search for bone mass QTLsR01AG026564 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2007 to 2010
$2.3M
Genetics of Osteoporotic Fractures in ChineseR03TW008221 · FIC · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2009 to 2011
$171k
FIC NIH HHS R03 TW008221NCI NIH HHS R01 CA129488NIAMS NIH HHS P50 AR055081NIAMS NIH HHS R01 AR050496NIAMS NIH HHS R01 AR057049NIA NIH HHS R01 AG026564
6 · The paper itself

Abstract

The level of serum 25-Hydroxyvitamin D [25(OH)D] has high heritability, suggesting that genes may contribute to variations in serum 25(OH)D level and vitamin D dose-response. As vitamin D deficiency has been linked to numerous diseases, understanding how genetic variation contributes to vitamin D dose-response is important for personalized vitamin D treatment and cost-effective disease prevention. To identify genetic variants responsible for vitamin D status and dose-response, we performed two vitamin D3 and calcium clinical supplementation trials in 2,207 postmenopausal Caucasian women. We examined the association of 291 SNPs with baseline serum 25(OH)D levels and 25(OH)D dose-response. Five SNPs, rs10500804 (P = 4.93 × 10

Indexed as

Dietary SupplementsCholecalciferolDose-Response Relationship, DrugFemaleHumansMiddle AgedPolymorphism, Single NucleotidePostmenopauseRetinoid X Receptor alphaVitamin D25-hydroxyvitamin DCholecalciferolRetinoid X Receptor alphaVitamin D

Identifiers

PMID28079136
PMCPMC5228186
OpenAlexW2576311131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.