ArticleScientific reports2017
Functional Nanoarchitectures For Enhanced Drug Eluting Stents.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Study on Mechanical Properties of Nanopores in CoCrFeMnNi High-Entropy Alloy Used as Drug-Eluting Stent.Materials (Basel, Switzerland) · 2024Article
- Fine-Tuning the Nanostructured Titanium Oxide Surface for Selective Biological Response.ACS applied bio materials · 2023Article
- Biocompatibility and Mechanical Stability of Nanopatterned Titanium Films on Stainless Steel Vascular Stents.International journal of molecular sciences · 2022Article
- Regulatory perspectives of combination products.Bioactive materials · 2022Review
- 3D Printing of Polymeric Bioresorbable Stents: A Strategy to Improve Both Cellular Compatibility and Mechanical Properties.Polymers · 2022Review
- Applying Principles of Regenerative Medicine to Vascular Stent Development.Frontiers in bioengineering and biotechnology · 2022Review
- Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy.APL bioengineering · 2021Review
- Core-Shell Pluronic-Organosilica Nanoparticles with Controlled Polarity and Oxygen Permeability.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Drug-Eluting Stents and Balloons-Materials, Structure Designs, and Coating Techniques: A Review.Molecules (Basel, Switzerland) · 2020Review
- Superelasticity Evaluation of the Biocompatible Ti-17Nb-6Ta Alloy.Journal of healthcare engineering · 2019Article
- Cardiovascular stents: overview, evolution, and next generation.Progress in biomaterials · 2018Review
- Recent advances to accelerate re-endothelialization for vascular stents.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different strategies have been investigated to allow for optimum duration and conditions for endothelium healing through the enhancement of coronary stents. In this study, a nanoarchitectured system is proposed as a surface modification for drug eluting stents. Highly oriented nanotubes were vertically grown on the surface of a new Ni-free biocompatible Ti-based alloy, as a potential material for self-expandable stents. The fabricated nanotubes were self-grown from the potential stent substrate, which are also proposed to enhance endothelial proliferation while acting as drug reservoir to hinder Vascular Smooth Muscle Cells (VSMC) proliferation. Two morphologies were synthesized to investigate the effect of structure homogeneity on the intended application. The material was characterized by field-emission scanning electron microscope (FESEM), X-ray diffraction (XRD), Raman spectroscopy, energy dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS). Nanoindentation technique was used to study the mechanical properties of the fabricated material. Cytotoxicity and proliferation studies were performed and compared for the two fabricated nanoarchitectures, versus smooth untextured samples, using in-vitro cultured endothelial cells. Finally, the drug loading capacity was experimentally studied and further supported by computational modeling of the release profile.
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Registered trials
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