ArticleThe Journal of comparative neurology2019
Expression of transcription factors divides retinal ganglion cells into distinct classes.
Article in The Journal of comparative neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Analysis of retinal ganglion cell subtypes across six different inbred mouse strains.Molecular vision · 2026Article
- Retinal ganglion cell circuits and glial interactions in humans and mice.Trends in neurosciences · 2024Review
- Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.Neuron · 2024Article
- POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells.Scientific reports · 2024Article
- Evaluation of the neuroprotective efficacy of the gramine derivative ITH12657 against NMDA-induced excitotoxicity in the rat retina.Frontiers in neuroanatomy · 2024Article
- Article
- Retinal self-organization: a model of retinal ganglion cells and starburst amacrine cells mosaic formation.Open biology · 2023Article
- Vision-Dependent and -Independent Molecular Maturation of Mouse Retinal Ganglion Cells.Neuroscience · 2023Article
- Pou4f1-Tbr1 transcriptional cascade controls the formation of Jam2-expressing retinal ganglion cells.Frontiers in ophthalmology · 2023Article
- Retinal patterns and the cellular repertoire of neuropsin (Opn5) retinal ganglion cells.The Journal of comparative neurology · 2022Article
- Satb1 expression in retinal ganglion cells of marmosets, macaques, and humans.The Journal of comparative neurology · 2022Article
- Case report: ISL2 is involved in malignant transformation in a patient with multiple relapsed oligodendroglioma.Frontiers in oncology · 2022Article
- Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells.BMC genomics · 2021Article
- VEGFD Protects Retinal Ganglion Cells and, consequently, Capillaries against Excitotoxic Injury.Molecular therapy. Methods & clinical development · 2020Article
- Neurogenesis and Specification of Retinal Ganglion Cells.International journal of molecular sciences · 2020Review
- Article
- Molecular Fingerprinting of On-Off Direction-Selective Retinal Ganglion Cells Across Species and Relevance to Primate Visual Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Tbr1 instructs laminar patterning of retinal ganglion cell dendrites.Nature neuroscience · 2018Article
- Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells.Stem cell reports · 2018Article
- Large scale matching of function to the genetic identity of retinal ganglion cells.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Retinal ganglion cells (RGCs) are tasked with transmitting all light information from the eye to the retinal recipient areas of the brain. RGCs can be classified into many different types by morphology, gene expression, axonal projections, and functional responses to different light stimuli. Ultimately, these classification systems should be unified into an all-encompassing taxonomy. Toward that end, we show here that nearly all RGCs express either Islet-2 (Isl2), Tbr2, or a combination of Satb1 and Satb2. We present gene expression data supporting the hypothesis that Satb1 and Satb2 are expressed in ON-OFF direction-selective (DS) RGCs, complementing our previous work demonstrating that RGCs that express Isl2 and Tbr2 are non-DS and non-image-forming, respectively. Expression of these transcription factors emerges at distinct embryonic ages and only in postmitotic cells. Finally, we demonstrate that these transcription factor-defined RGC classes are born throughout RGC genesis.
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