Evidence map›Paper›PMID 28078614›Full record

ArticleNeurochemical research2017

Resistance Exercise Reduces Seizure Occurrence, Attenuates Memory Deficits and Restores BDNF Signaling in Rats with Chronic Epilepsy.

Alexandre Aparecido de Almeida, Sérgio Gomes da Silva, Glauber Menezes Lopim, Diego Vannucci Campos, Jansen Fernandes, Francisco Romero Cabral, Ricardo Mario Arida

Abstract read
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In one paragraph

Article in Neurochemical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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  14. The Contribution of Physical Exercise to Brain Resilience.Frontiers in behavioral neuroscience · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexandre Aparecido de AlmeidaDepartamento de Fisiologia, Universidade Federal de São Paulo, Rua Botucatu 862, Ed. Ciências Biomédicas, 5° andar. Vila Clementino, São Paulo, SP, 04023-900, Brazil.
Sérgio Gomes da SilvaHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Glauber Menezes LopimDepartamento de Fisiologia, Universidade Federal de São Paulo, Rua Botucatu 862, Ed. Ciências Biomédicas, 5° andar. Vila Clementino, São Paulo, SP, 04023-900, Brazil.
Diego Vannucci CamposDepartamento de Fisiologia, Universidade Federal de São Paulo, Rua Botucatu 862, Ed. Ciências Biomédicas, 5° andar. Vila Clementino, São Paulo, SP, 04023-900, Brazil.
Jansen FernandesDepartamento de Fisiologia, Universidade Federal de São Paulo, Rua Botucatu 862, Ed. Ciências Biomédicas, 5° andar. Vila Clementino, São Paulo, SP, 04023-900, Brazil.
Francisco Romero CabralHospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Ricardo Mario AridaDepartamento de Fisiologia, Universidade Federal de São Paulo, Rua Botucatu 862, Ed. Ciências Biomédicas, 5° andar. Vila Clementino, São Paulo, SP, 04023-900, Brazil. arida.nexp@epm.br.
Universidade Federal de São Paulo · BRFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRUniversidade de Mogi das Cruzes · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a disease characterized by recurrent, unprovoked seizures. Cognitive impairment is an important comorbidity of chronic epilepsy. Human and animal model studies of epilepsy have shown that aerobic exercise induces beneficial structural and functional changes and reduces the number of seizures. However, little is yet understood about the effects of resistance exercise on epilepsy. We evaluated the effects of a resistance exercise program on the number of seizures, long-term memory and expression/activation of signaling proteins in rats with epilepsy. The number of seizures was quantified by video-monitoring and long-term memory was assessed by an inhibitory avoidance test. Using western blotting, multiplex and enzyme-linked immunosorbent assays, we determined the effects of a 4-week resistance exercise program on IGF-1 and BDNF levels and ERK, CREB, mTOR activation in the hippocampus of rats with epilepsy. Rats with epilepsy submitted to resistance exercise showed a decrease in the number of seizures compared to non-exercised epileptic rats. Memory deficits were attenuated by resistance exercise. Rats with epilepsy showed an increase in IGF-1 levels which were restored to control levels by resistance exercise. BDNF levels and ERK and mTOR activation were decreased in rats with epilepsy and resistance exercise restored these to control levels. In conclusion, resistance exercise reduced seizure occurrence and mitigated memory deficits in rats with epilepsy. These resistance exercise-induced beneficial effects can be related to changes in IGF-1 and BDNF levels and its signaling protein activation. Our findings indicate that the resistance exercise might be included as complementary therapeutic strategy for epilepsy treatment.

Indexed as

AnimalsAvoidance LearningBrain-Derived Neurotrophic FactorEpilepsyMaleMemory DisordersPhysical Conditioning, AnimalRatsResistance TrainingSeizuresBrain-Derived Neurotrophic FactorBDNFEpilepsyIGF-1Long-term memoryResistance exerciseSeizures

Identifiers

PMID28078614
OpenAlexW2578312300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.