ReviewSurgical endoscopy2017
Endoscopic vacuum therapy for various defects of the upper gastrointestinal tract.
Review in Surgical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04670276 (Conservative Treatment of Gastrointestinal Fistulas by Endoscopic Injection of Emulsified Adipose Tissue Stromal Vascular Fraction), which is not on this map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Conservative Treatment of Gastrointestinal Fistulas by Endoscopic Injection of Emulsified Adipose Tissue Stromal Vascular Fraction (tSVFem)
Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Update on therapeutic strategy for esophageal anastomotic leak: A systematic literature review.Thoracic cancer · 2023Pooled it
- Endoscopic Treatment Options for Gastrointestinal Leaks.Visceral medicine · 2022Pooled it
- Management of intra-thoracic anastomotic leakages after esophagectomy: updated systematic review and meta-analysis of endoscopic vacuum therapy versus stenting.BMC surgery · 2022Pooled it
- Critical Appraisal of the Impact of Oesophageal Stents in the Management of Oesophageal Anastomotic Leaks and Benign Oesophageal Perforations: An Updated Systematic Review.World journal of surgery · 2020Pooled it
- Indigenously modified endoluminal vacuum-assisted closure therapy for post-operative gastrointestinal transmural defects: Case series and review of literature.Journal of minimal access surgery · 2026Article
- Article
- Pilot Study of a Novel Device for Endoscopic Vacuum Therapy for Anastomotic Leak.ACG case reports journal · 2026Article
- Evidence-based, cost-effective management of nontraumatic esophageal perforations: An algorithm of the Journal of Trauma and Acute Care Surgery Emergency General Surgery Algorithms Work Group.The journal of trauma and acute care surgery · 2026Article
- Endoluminal vacuum therapy for upper gastrointestinal leaks: safe, effective and minimally invasive - insights from a retrospective observational study.Surgical endoscopy · 2026Observational
- Endoscopic treatment of gastrointestinal perforations and leaks: Why, when, and how?World journal of gastrointestinal endoscopy · 2026Review
- Endoscopic management for gastrointestinal leaks, perforations, and fistulae: Technical tips and outcomes.World journal of gastrointestinal endoscopy · 2025Review
- Closing the gap: endoscopic treatment of esophageal anastomotic leakage-a retrospective cohort study.Surgical endoscopy · 2025Article
- Transcatheter arterial embolization for acute nonvariceal upper Gastrointestinal bleeding in children: a single-center retrospective study.BMC surgery · 2025Article
- Exploring the boundaries of anastomotic leak: experience in a high-volume center.World journal of surgical oncology · 2025Review
- VACStent closure of oesophageal defects by covered stent and endoscopic vacuum therapy: initial use and clinical outcomes.Journal of surgical case reports · 2025Article
- VAC-Stent in the Treatment of Post-Esophagectomy Anastomotic Leaks: A New "Kid on the Block" Who Marries the Best of Old Techniques-A Review.Journal of clinical medicine · 2024Review
- Endoscopic self-expandable metal stent versus endoscopy vacuum therapy for traumatic esophageal perforations: a retrospective cohort study.Surgical endoscopy · 2024Article
- Endoscopic Intervention for Anastomotic Leakage After Gastrectomy.Journal of gastric cancer · 2024Review
- The Role of Open-Pore Film Drainage Systems in Endoscopic Vacuum Therapy: Current Status and Review of the Literature.Visceral medicine · 2024Review
- Understanding Post-Esophagectomy Complications and Their Management: The Early Complications.Journal of clinical medicine · 2023Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative, iatrogenic or spontaneous upper gastrointestinal defects result in significant morbidity and mortality of the patients. In the last few years, endoscopic vacuum therapy (EVT) has been recognized as a new promising method for repairing upper gastrointestinal defects of different etiology. However, probably due to insufficient data and no commercially available system for EVT of the upper gastrointestinal tract, until the end of 2014, covering of esophageal defects with self-expanding metal stents (SEMS) were still the mainstay of endoscopic therapy. The aim of this article is to review the data available about EVT for various upper gastrointestinal defects.
methodsA selective literature search was conducted in Medline and PubMed (2007-2016), taking into account all the published case series and case reports reporting on the use of EVT in the management of upper gastrointestinal defects.
resultsEVT works through intracorporal application of negative pressure at the defect zone with an electronic controlled vacuum device along a polyurethane sponge drainage. This results in closure of the esophageal defect and internal drainage of the septic focus, simultaneously. Compared to stenting, EVT enables regular viewing of wound conditions with control of the septic focus and adjustment of therapy. Moreover, endoscopical negative pressure is applicable in all esophageal regions (cricopharygeal, tubular, gastroesophageal junction) and in anastomotic anatomic variants. EVT can be used solely as a definite treatment or as a complimentary therapy combined with operative revision. In total, there are published data of more than 200 patients with upper gastrointestinal defects treated with EVT, showing succes rates from 70-100%.
conclusionThe available data indicate that EVT is feasible, safe and effective with good short-term and long-term clinical outcomes in the damage control of upper GI-tract leaks. Still, a prospective multi-center study has to be conducted to proof the definite benefit of EVT for patients with esophageal defects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.