ArticleAnnals of clinical and translational neurology2017
Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype.
Article in Annals of clinical and translational neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01720810 (Pacific Northwest Udall Center), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pacific Northwest Udall Center (PANUC) Clinical Core
Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- The GBA1-related variant rs12411216 is Associated with Motor and Non-Motor Impairments and Unfavorable Progression in Parkinson's Disease: A Five-Year Longitudinal Study.Journal of molecular neuroscience : MN · 2026Article
- Brain functional mechanisms of acupuncture treatment for early-stage non-tremor Parkinson's disease: a resting-state fMRI study.Frontiers in neurology · 2026Observational
- Parkinson DiseaseNeurology. Genetics · 2025Article
- GWAS by Subtraction to Disentangle RBD Genetic Background from α-Synucleinopathies.International journal of molecular sciences · 2025Article
- Genetics of Parkinson's disease heterogeneity: A genome-wide association study of clinical subtypes.Parkinsonism & related disorders · 2024Article
- The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein.Human molecular genetics · 2023Article
- Parkinson's Disease Subtyping Using Clinical Features and Biomarkers: Literature Review and Preliminary Study of Subtype Clustering.Diagnostics (Basel, Switzerland) · 2022Review
- Genetic architecture of Parkinson's disease subtypes - Review of the literature.Frontiers in aging neuroscience · 2022Review
- Genetic Elements at the Alpha-Synuclein Locus.Frontiers in neuroscience · 2022Review
- Endophenotypical drift in Huntington's disease: a 5-year follow-up study.Orphanet journal of rare diseases · 2021Article
- Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.NPJ Parkinson's disease · 2021Review
- A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease.NPJ Parkinson's disease · 2021Review
- Genetics of synucleins in neurodegenerative diseases.Acta neuropathologica · 2021Review
- Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes.Neurology. Genetics · 2021Article
- Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson's Disease Risk.Frontiers in cellular neuroscience · 2021Review
- Association ofFrontiers in neurology · 2020Article
- Identifying and predicting Parkinson's disease subtypes through trajectory clustering via bipartite networks.PloS one · 2020Article
- Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2020Review
- Whole Exome Sequencing Study of Parkinson Disease and Related Endophenotypes in the Italian Population.Frontiers in neurology · 2019Article
- Parkinson's disease and Alzheimer's disease: a Mendelian randomization study.BMC medical genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveParkinson's disease (PD) presents clinically with several motor subtypes that exhibit variable treatment response and prognosis. Here, we investigated genetic variants for their potential association with PD motor phenotype and progression.
methodsWe screened 10 SNPs, previously associated with PD risk, for association with tremor-dominant (TD) versus postural-instability gait disorder (PIGD) motor subtypes. SNPs that correlated with the TD/PIGD ratio in a discovery cohort of 251 PD patients were then evaluated in a multi-site replication cohort of 559 PD patients. SNPs associated with motor phenotype in both cross-sectional cohorts were next evaluated for association with (1) rates of motor progression in a longitudinal subgroup of 230 PD patients and (2) brain alpha-synuclein (
resultsGenotype at rs356182, near
interpretationOur study demonstrates that the GG genotype at rs356182 provides molecular definition for a clinically important endophenotype associated with (1) more tremor-predominant motor phenomenology, (2) slower rates of motor progression, and (3) decreased brain expression of
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.