Evidence map›Paper›PMID 28078280›Full record

ArticleBioMed research international2016

Protective Effects of Emodin-Induced Neutrophil Apoptosis via the Ca

Gui-Jun Wang, Yue Wang, Yong-Sheng Teng, Fa-Lv Sun, Hong Xiang, Jian-Jun Liu, Shi-Lin Xia, Gui-Xin Zhang, Hai-Long Chen, Dong Shang

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  13. Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Gui-Jun WangPancreaticobiliary Centre, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, China.
Yue WangPancreaticobiliary Centre, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, China.
Yong-Sheng TengCollege of Integrative Medicine, Dalian Medical University, Dalian, Liaoning 116044, China.
Fa-Lv SunCollege of Integrative Medicine, Dalian Medical University, Dalian, Liaoning 116044, China.
Hong XiangCollege of Integrative Medicine, Dalian Medical University, Dalian, Liaoning 116044, China.
Jian-Jun LiuClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, China.
Shi-Lin XiaClinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, China.
Gui-Xin ZhangPancreaticobiliary Centre, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, China.
Hai-Long ChenPancreaticobiliary Centre, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, China.ORCID 0000-0002-1101-1990
Dong ShangPancreaticobiliary Centre, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116044, China.ORCID 0000-0003-1030-916X
Dalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects of emodin against SAP with SIRS. However, the exact mechanism underlying the effect of emodin remains unclear. This study was designed to explore the protective effects and underlying mechanisms of emodin against SIRS in rats with SAP. In the present study, cytosolic Ca

Indexed as

AcrylatesAnimalsApoptosisCalciumCalpainCaspase 12Caspase 3EmodinGene Expression RegulationHumansInflammationNeutrophilsPancreatitisRatsSignal TransductionAcrylatesCalciumCalpainCapn1 protein, ratCasp12 protein, ratCaspase 12Caspase 3EmodinPD 150606

Identifiers

PMID28078280
PMCPMC5203873
OpenAlexW2565526143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.