ReviewTranslational andrology and urology2016
Testicular compartment syndrome: an overview of pathophysiology, etiology, evaluation, and management.
Review in Translational andrology and urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Effectiveness of tunica albuginea incision and tunica vaginalis flap for testicular torsion: a systematic review.World journal of urology · 2025Pooled it
- Beyond Recurrence: Impact of Surgical Technique on Testicular Microcirculation After Inguinal Hernia Repair.BMC surgery · 2026Article
- Testicular Compartment Syndrome Post Bilateral Microdissection Testicular Sperm Extraction: A Case Report and Review of the Current Literature.Case reports in urology · 2026Article
- Testicular Two-Dimensional Shear Wave Elastography, Peak Systolic Velocity, Volume and Epididymal Thickness: Establishment of Normal Reference Values and Discrimination From Orchitis in Adult Patients Presenting With Acute Scrotal Pain.Australasian journal of ultrasound in medicine · 2025Article
- All pain, no gain: When epididymitis drops the ball.Radiology case reports · 2025Article
- Causal relationship between varicose veins and hydrocele: A bidirectional two-sample Mendelian randomization study.SAGE open medicine · 2025Article
- Analysis of misdiagnosis and mistreatment of 11 cases of non-tuberculous testicular abscess: case series.AME case reports · 2025Article
- Comparison of the size of bilateral testis in children with unilateral non-communicating hydrocele and its correlation with age.PloS one · 2023Article
- Testicular compartment syndrome: An unexpected diagnosis in a case of testicular pain.Urology case reports · 2021Article
- Ultrasound of scrotal and penile emergency: how, why and when.Journal of ultrasound · 2021Article
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- Testicular ischemia secondary to epididymo-orchitis: A case report.Urology case reports · 2019Article
- Microcirculatory effects of sildenafil in experimental testicular torsion in rats.World journal of urology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testicular compartment syndrome (TCS) refers to the impairment of microcirculation in the testicle due to either increased venous resistance or extraluminal compression, which leads to hypoxia. TCS releases oxidants through hypoxia and ischemia/reperfusion injury (IRI). The pathophysiology, etiology, evaluation, and management of TCS are reviewed. Based on the properties of TCS, specific causes, e.g., varicocele, hydrocele, orchitis, cryptorchidism, and scrotal hernia, are suggested and categorized. The oxidant-induced stress from TCS may explain the correlations between these causes and infertility. A chief shortcoming of current imaging modalities is that they detect TCS late after it has progressed to impair the macrocirculation of the testicle. We propose frequent sequential periodic power Doppler ultrasonography to monitoring for earlier detection. Intraoperatively, TCS can be diagnosed by the dull purple appearance of a hypoxic testicle and by tissue pressures above 30 mmHg. When compartment pressure is low, the underlying etiology must be promptly treated. During acute presentation, an incision of the resilient tunica albuginea may be necessary. A great challenge of treating TCS is restoring microcirculation while minimizing IRI; concomitant antioxidant therapy secondary to treatment may be effective and harmless at the least. Because testicular oxidant stress is common in infertility and since TCS can cause such a stress, TCS may be a larger factor in infertility than currently suspected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.