Evidence map›Paper›PMID 28078206›Full record

ArticleWorld journal of psychiatry2016

Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study.

Vladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Margot Mutsch, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Enrique Castelao and 8 more

Open access · hybridAbstract read
In one paragraph

Article in World journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Vladeta Ajdacic-GrossVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Aleksandra AleksandrowiczVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Stephanie RodgersVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Margot MutschVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Anja TesicVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Mario MüllerVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Wolfram KawohlVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Wulf RösslerVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Erich SeifritzVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Enrique CastelaoVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Marie-Pierre F StrippoliVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Caroline VandeleurVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Roland von KänelVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Rosa PaolicelliVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Markus A LandoltVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Cornelia WitthauerVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Roselind LiebVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
Martin PreisigVladeta Ajdacic-Gross, Aleksandra Aleksandrowicz, Stephanie Rodgers, Anja Tesic, Mario Müller, Wolfram Kawohl, Wulf Rössler, Erich Seifritz, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, 8021 Zurich, Switzerland.
University Psychiatric Hospital · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.

methodsWe used data from PsyCoLaus, a large Swiss Population Cohort Study (

resultsAssociations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women).

conclusionInfectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced.

Indexed as

Atopic diseasesChildhood diseasesChronic inflammatory diseasesInfectious diseasesMental disordersNeurodevelopmental disordersRisk factorsSubstance abuse

Identifiers

PMID28078206
PMCPMC5183994
OpenAlexW2565466103

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.