ReviewAmerican journal of neurodegenerative disease2016
Metabolic, inflammatory, and microvascular determinants of white matter disease and cognitive decline.
Review in American journal of neurodegenerative disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Arterial stiffness measured by pulse wave velocity correlated with cognitive decline in hypertensive individuals: a systematic review.BMC neurology · 2024Pooled it
- The Association Between Sleep and Metabolic Syndrome: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2020Trial
- Association Between Insulin Resistance, Plasma Leptin, and Neurocognition in Vascular Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2019Trial
- The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Review
- A structural heart-brain axis mediates the association between cardiovascular risk and cognitive function.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Brain Endothelial Cells Activate Neuroinflammatory Pathways in Response to Early Cerebral Small Vessel Disease (CSVD) Patients' Plasma.Biomedicines · 2023Article
- Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain.Communications biology · 2023Article
- The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr-/-.Leiden Mice.Nutrients · 2023Article
- White matter hyperintensities are an independent predictor of cognitive decline 3 years following first-ever stroke-results from the PROSCIS-B study.Journal of neurology · 2023Article
- Leukoencephalopathy in children with acute lymphoblastic leukemia after chemotherapy: a retrospective monocenter study.Translational cancer research · 2023Article
- Overweight/Obesity-related microstructural alterations of the fimbria-fornix in the ABCD study: The role of aerobic physical activity.PloS one · 2023Article
- Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults.Nutrients · 2022Article
- Obstructive sleep apnea and white matter hyperintensities: correlation or causation?Brain imaging and behavior · 2022Article
- Clinical and MRI features about two types of silent cerebral small-vessel disease in type-2 diabetes mellitus: a retrospective cross-sectional study in a tertiary hospital.Quantitative imaging in medicine and surgery · 2022Article
- Vascular risk profile and white matter hyperintensity volume among Mexican Americans and non-Hispanic Whites: The HABLE study.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Baseline associations between biomarkers, cognitive function, and self-regulation indices in the Cognitive and Self-regulatory Mechanisms of Obesity Study.Obesity science & practice · 2021Article
- Clinically Silent Small Vessel Disease of the Brain in Patients with Obstructive Sleep Apnea Hypopnea Syndrome.Diagnostics (Basel, Switzerland) · 2021Article
- Role of White Matter Hyperintensities and Related Risk Factors in Vascular Cognitive Impairment: A Review.Biomolecules · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
White Matter Disease is increasingly being recognized as an important cause of cognitive decline and dementia. Various investigations have linked chronic diet-related conditions to the development of white matter lesions, which appear as white matter hyperintensities on T2-weighted magnetic resonance imaging (MRI) scans of the brain. Thus, it can be postulated that the metabolic, inflammatory, and microvascular changes accompanying a western diet, hyperlipidemia, hypertension, and diabetes mellitus type II (DMII) are potential mediators in the development and progression of white matter disease, which in turn contributes to the development and progression of cognitive decline. This review will examine evidence for potential metabolic, inflammatory, and microvascular determinants of white matter disease and cognitive decline. Specifically, we will focus on the effects of altered insulin signaling in diabetes, obesity-induced oxidative stress, neuroinflammation, arterial stiffness due to hypertension, ischemia secondary to cerebral small vessel disease, and blood brain barrier disturbances.
Indexed as
Identifiers
28078193PMC5218857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.