ArticleInternational journal of burns and trauma2016
Effects of the nephrilin peptide on post-burn glycemic control, renal function, fat and lean body mass, and wound healing.
Article in International journal of burns and trauma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Covalent modification of nephrilin peptide with valproic acid increases its efficacy as a therapeutic in burn trauma.Burns open : an international open access journal for burn injuries · 2020Article
- Epigenetic memory of oxidative stress: does nephrilin exert its protective effects via Rac1?Biologics : targets & therapy · 2017Article
- Positive effects of ferric iron on the systemic efficacy of nephrilin peptide in burn trauma.Scars, burns & healingArticle
- Transcriptional re-programming in rat central nervous system two weeks after burn trauma: the impact of nephrilin treatment on the expression of oxidative stress-related genes.Scars, burns & healingArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the effects of severe burn trauma are not well understood. We previously demonstrated the ability of nephrilin peptide (an iron-binding peptide believed to enter cells through iron-uptake pathways) to suppress aspects of the neuroinflammatory response in a rat scald model, as well as sepsis mortality in a mouse model. This study explores the effect of nephrilin on other clinically relevant outcomes in the rat scald model. In a rat scald model, animals were treated with nephrilin either in week 1 or week 2 post-burn. Measurements were made of serum glucose and creatinine as well as wound area by planimetry and body composition by DEXA. Given the potential role of iron, results were analyzed both for the entire cohort of animals and for the normoferremic (>100 ug/dL serum iron) subset of animals. Nephrilin improved body composition, wound healing, kidney function, and glycemic control. The first two effects were significant in normoferremic but not in hypoferremic animals suggesting an effect of iron status on burn injury outcomes. Nephrilin treatment modulates a number of relevant variables in the rat scald model.
Indexed as
Identifiers
28078180PMC5218868What OpenQuestion holds
Registered trials
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