ArticleAmerican journal of cardiovascular disease2016
The function of cathepsins B, D, and X in atherosclerosis.
Article in American journal of cardiovascular disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Proteomic Signatures of High-Risk Coronary Plaque Features and Incident Events.JACC. Basic to translational science · 2026Article
- Novel Cerebrovascular Disease Blood Biomarkers Identified by Targeted Proteomics in a High-Risk Native American Population.World neurosurgery · 2026Article
- Integrative Analysis on the Urinary Proteome of Diabetic Kidney Disease, with an Emphasis on Extracellular Matrix Proteins.International journal of molecular sciences · 2026Article
- Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments.GeroScience · 2025Review
- Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Macrophage-based pathogenesis and theranostics of vulnerable plaques.Theranostics · 2025Review
- Article
- Immunological perspectives on atherosclerotic plaque formation and progression.Frontiers in immunology · 2024Review
- Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia.JCI insight · 2023Article
- Atherosclerosis treatment with nanoagent: potential targets, stimulus signals and drug delivery mechanisms.Frontiers in bioengineering and biotechnology · 2023Review
- Vulnerable Atherosclerotic Plaque: Is There a Molecular Signature?International journal of molecular sciences · 2022Review
- Changes to Urinary Proteome in High-Fat-DietBiomolecules · 2022Article
- New insights into macrophage subsets in atherosclerosis.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Functional Analysis of the Cathepsin D Gene Response to SGIV Infection in the Orange-Spotted Grouper,Viruses · 2022Article
- Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture.Scientific reports · 2022Article
- New multienzymatic complex formed between human cathepsin D and snake venom phospholipase AThe journal of venomous animals and toxins including tropical diseases · 2022Article
- Enzyme-activated probes in optical imaging: a focus on atherosclerosis.Dalton transactions (Cambridge, England : 2003) · 2021Review
- Oxidized Lipids: Common Immunogenic Drivers of Non-Alcoholic Fatty Liver Disease and Atherosclerosis.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cathepsins are proteolytic enzymes typically located within the lysosomes of macrophages. Once released, they can enhance the inflammatory process in atherosclerosis. Cathepsin X aids in the migration of T-lymphocytes and the release of cytokines. Cathepsin D modifies low-density lipoprotein to promote its uptake by macrophages and its subsequent foam cell formation. Furthermore, cathepsin D regulates apoptosis. Cathepsin B degrades the extracellular matrix within the arterial intima. Together, they increase plaque vulnerability. This evidence suggests that cathepsins play an important role in the pathogenesis of atherosclerosis.
Indexed as
Identifiers
28078176PMC5218848W3021579651What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.