Evidence map›Paper›PMID 28078110›Full record

ArticleJournal of gastrointestinal oncology2016

Radioembolization with

Nicholas Fidelman, Robert K Kerlan, Randall A Hawkins, Miguel Pampaloni, Andrew G Taylor, Maureen P Kohi, K Pallav Kolli, Chloe E Atreya, Emily K Bergsland, R Kate Kelley and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of gastrointestinal oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Detection of Shortwave-Infrared Cerenkov Luminescence from Medical Isotopes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Liver transarterial embolizations in metastatic neuroendocrine tumors.Reviews in endocrine & metabolic disorders · 2017
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Nicholas FidelmanDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Robert K KerlanDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Randall A HawkinsDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Miguel PampaloniDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Andrew G TaylorDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Maureen P KohiDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
K Pallav KolliDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Chloe E AtreyaDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Emily K BergslandDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
R Kate KelleyDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Andrew H KoDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
W Michael KornDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Katherine Van LoonDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Ryan M McWhirterDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Jennifer LuanDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Curt JohansonDepartment of Radiology, University of California San Francisco, San Francisco, CA, USA.
Alan P VenookDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Targeting of Aberrant Signaling in Patient-Derived Colorectal Cancer ModelsK08CA175153 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ATREYA, CHLOE E. · 2013 to 2017
$867k
NCI NIH HHS K08 CA175153
6 · The paper itself

Abstract

backgroundThis prospective pilot single-institution study was undertaken to document the feasibility, safety, and efficacy of radioembolization of liver-dominant metastatic gastrointestinal cancer using

methodsBetween June 2010 and October 2013, 42 adult patients (26 men, 16 women; median age 60 years) with metastatic chemotherapy-refractory unresectable colorectal (n=21), neuroendocrine (n=11), intrahepatic bile duct (n=7), pancreas (n=2), and esophageal (n=1) carcinomas underwent 60 lobar or segmental administrations of

resultsMedian target dose and activity were 109.4 Gy and 2.6 GBq per treatment session, respectively. Majority of clinical AE were grade 1 or 2 in severity. Patients with colorectal cancer had hepatic objective response rate (ORR) of 25% and a hepatic disease control rate (DCR) of 80%. Median PFS and OS were 1.0 and 4.4 months, respectively. Patients with neuroendocrine tumors (NET) had hepatic ORR and DCR of 73% and 100%, respectively. Median PFS was 8.9 months for this cohort. DCR and median PFS and OS for patients with cholangiocarcinoma were 86%, 1.1 months, and 6.7 months, respectively.

conclusions

Indexed as

Livermetastasesradioembolizationyttrium-90 glass microspheres

Identifiers

PMID28078110
PMCPMC5177572
OpenAlexW2521332320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.