Evidence map›Paper›PMID 28078102›Full record

ArticleConcussion (London, England)2016

Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus.

Rebecca Acabchuk, Denise I Briggs, Mariana Angoa-Pérez, Meghan Powers, Richard Wolferz, Melanie Soloway, Mai Stern, Lillian R Talbot, Donald M Kuhn, Joanne C Conover

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Concussion (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Inflammation in Traumatic Brain Injury.Journal of Alzheimer's disease : JAD · 2020
    Review
  6. Review
  7. Article
  8. Dangers of Mixed Martial Arts in the Development of Chronic Traumatic Encephalopathy.International journal of environmental research and public health · 2019
    Article
  9. Review
  10. Helmets in women's lacrosse: what the evidence shows.Concussion (London, England) · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Rebecca AcabchukDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Denise I BriggsJohn D Dingell VA Medical Center and Wayne State University School of Medicine, Detroit, MI 48201, USA.
Mariana Angoa-PérezJohn D Dingell VA Medical Center and Wayne State University School of Medicine, Detroit, MI 48201, USA.
Meghan PowersDepartment of Biological Engineering, Cornell University, Ithaca, NY 14853, USA.
Richard WolferzDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Melanie SolowayDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Mai SternDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Lillian R TalbotDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
Donald M KuhnJohn D Dingell VA Medical Center and Wayne State University School of Medicine, Detroit, MI 48201, USA.
Joanne C ConoverDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA ; Institute for Brain and Cognitive Sciences, University of Connecticut, Storrs, CT 06269, USA.
University of Connecticut · USWayne State University · USCornell University · USJohn D. Dingell VA Medical Center · US

Funding

Repeated Mild Traumatic Brain Injury and its Impact on Ventricle System HealthR21NS090092 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI CONOVER, JOANNE C · 2014 to 2015
$417k
TBI & Alcohol Abuse: Co-occurring Conditions that Enhance Brain DamageI01RX000375 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI KUHN, DONALD M · 2012 to 2015
–
RR&D Research Career Scientist Award ApplicationIK6RX002419 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI KUHN, DONALD M · 2017 to 2023
–
NINDS NIH HHS R21 NS090092RRD VA I01 RX000375RRD VA IK6 RX002419
6 · The paper itself

Abstract

aimTo advance our understanding of regional and temporal cellular responses to repeated mild traumatic brain injury (rmTBI), we used a mouse model of rmTBI that incorporated acceleration, deceleration and rotational forces. MATERIALS &

methodsA modified weight-drop method was used to compare two inter-injury intervals, rmTBI-short (five hits delivered over 3 days) and rmTBI-long (five hits delivered over 15 days). Regional investigations of forebrain and midbrain histological alterations were performed at three post-injury time points (immediate, 2 weeks and 6 weeks).

resultsThe rmTBI-short protocol generated an immediate, localized microglial and astroglial response in the dorsolateral septum and hippocampus, with the astroglial response persisting in the dorsolateral septum. The rmTBI-long protocol showed only a transitory astroglial response in the dorsolateral septum.

conclusionOur results indicate that the lateral septum and hippocampus are particularly vulnerable regions in rmTBI, possibly contributing to memory and emotional impairments associated with repeated concussions.

Indexed as

concussiongliosishippocampusmicrogliamouse modelrmTBIrotational forceseptum

Identifiers

PMID28078102
PMCPMC5222510
OpenAlexW2405748308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.