ArticleInternational journal of physiology, pathophysiology and pharmacology2016
Comparative changes in antioxidant enzymes and oxidative stress in cardiac, fast twitch and slow twitch skeletal muscles following endurance exercise training.
Article in International journal of physiology, pathophysiology and pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Effects of exercise on different antioxidant enzymes and related indicators: a systematic review and meta-analysis of randomized controlled trials.Scientific reports · 2025Pooled it
- Evaluation of the Efficacy of Supplementation with Planox® Lemon Verbena Extract in Improving Oxidative Stress and Muscle Damage: A Randomized Double-Blind Controlled Trial.International journal of medical sciences · 2021Trial
- Article
- Adolescent treadmill exercise enhances hippocampal brain-derived neurotrophic factor (BDNF) expression and improves cognition in autism-modeled rats.Physiology & behavior · 2024Article
- Exercise Training and Skeletal Muscle Antioxidant Enzymes: An Update.Antioxidants (Basel, Switzerland) · 2022Review
- Redox status biomarkers in the fast-twitch extensor digitorum longus resulting from the hypoxic exercise.Nagoya journal of medical science · 2022Article
- The "Angiogenic Switch" and Functional Resources in Cyclic Sports Athletes.International journal of molecular sciences · 2021Review
- The Regulatory Role of Oxygen Metabolism in Exercise-Induced Cardiomyocyte Regeneration.Frontiers in cell and developmental biology · 2021Review
- Effects of Prolonged Dietary Curcumin Exposure on Skeletal Muscle Biochemical and Functional Responses of Aged Male Rats.International journal of molecular sciences · 2019Article
- Article
- The effects of mid- and long-term endurance exercise on heart angiogenesis and oxidative stress.Iranian journal of basic medical sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The aim of this study was to evaluate exercise-induced transcriptional and protein responses of heart, soleus (slow oxidative), and plantaris (fast glycolytic) muscle in response to ten days of endurance exercise training. Four-month old female Sprague-Dawley rats were assigned to either a sedentary (SED) or endurance exercise-training (EXE) group (n=8 per group). The heart, plantaris, and soleus were excised and used for biochemical analyses. Our results show that heart and plantaris from EXE animals had higher protein levels of superoxide dismutase 2 (SOD2) compared to SED animals (P<0.05). Also, the protein levels of catalase were higher in plantaris of EXE animals compared to SED animals (P<0.05). No significant differences existed for 4 hydroxynonenal (4HNE) conjugated proteins (index of oxidative damage) in the three tissues between SED and EXE animals. mRNA levels of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) were higher in plantaris of EXE animals compared to SED animals (P<0.05), and mRNA levels of estrogen-related receptor alpha (ERRα) were lower in the heart of EXE animals compared to SED animals. In conclusion, heart and plantaris are responsive to ten days of treadmill training, while greater exercise intensities or durations may be needed to elicit alterations in soleus.
Indexed as
Identifiers
28078055PMC5209445W2988385571What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.