Evidence map›Paper›PMID 28078038›Full record

ArticleAmerican journal of translational research2016

Insulin resistance is associated with specific gut microbiota in appendix samples from morbidly obese patients.

Isabel Moreno-Indias, Lidia Sánchez-Alcoholado, Eduardo García-Fuentes, Fernando Cardona, Maria Isabel Queipo-Ortuño, Francisco J Tinahones

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 139 citations in OpenAlex.

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  8. Exercise benefits in metabolism on cardiovascular disease.Frontiers in cardiovascular medicine · 2026
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  11. Characteristic Gut Microbiota in PCOS-IR Patients and Its Association with Endocrine Features.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Isabel Moreno-IndiasClinical Management Unit of Endocrinology and Nutrition, Laboratory of The Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria University Hospital, Malaga UniversityMalaga, Spain; Biomedical Research Networking Center for Pathophysiology of Obesity and NutritionMadrid, Spain.
Lidia Sánchez-AlcoholadoClinical Management Unit of Endocrinology and Nutrition, Laboratory of The Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria University Hospital, Malaga University Malaga, Spain.
Eduardo García-FuentesBiomedical Research Networking Center for Pathophysiology of Obesity and NutritionMadrid, Spain; Clinical Management Unit of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Regional University HospitalMalaga, Spain.
Fernando CardonaClinical Management Unit of Endocrinology and Nutrition, Laboratory of The Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria University Hospital, Malaga UniversityMalaga, Spain; Biomedical Research Networking Center for Pathophysiology of Obesity and NutritionMadrid, Spain.
Maria Isabel Queipo-OrtuñoClinical Management Unit of Endocrinology and Nutrition, Laboratory of The Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria University Hospital, Malaga UniversityMalaga, Spain; Biomedical Research Networking Center for Pathophysiology of Obesity and NutritionMadrid, Spain.
Francisco J TinahonesClinical Management Unit of Endocrinology and Nutrition, Laboratory of The Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria University Hospital, Malaga UniversityMalaga, Spain; Biomedical Research Networking Center for Pathophysiology of Obesity and NutritionMadrid, Spain.
Victoria University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in intestinal microbiota composition could promote a proinflammatory state in adipose tissue that is associated with obesity and insulin resistance. Our aim was to identify the gut microbiota associated with insulin resistance in appendix samples from morbidly obese patients classified in 2 groups, high (IR-MO) and low insulin-resistant (NIR-MO), and to determine the possible association between these gut microbiota and variables associated with insulin resistance and the expression of genes related to inflammation and macrophage infiltration in adipose tissue. Appendix samples were obtained during gastric bypass surgery and the microbiome composition was determined by 16S rRNA pyrosequencing and bioinformatics analysis by QIIME. The Chao and Shannon indices for each study group suggested similar bacterial richness and diversity in the appendix samples between both study groups. 16S rRNA pyrosequencing showed that the IR-MO group had a significant increase in the abundance of

Indexed as

adipose tissueappendixgut integrityinflammationinsulin resistanceMicrobiota

Identifiers

PMID28078038
PMCPMC5209518
OpenAlexW2938977831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.