Evidence map›Paper›PMID 28077934›Full record

ArticleJournal of the International Society of Sports Nutrition2017

Serum reference value of two potential doping candidates-myostatin and insulin-like growth factor-I in the healthy young male.

Der-Sheng Han, Chi-Huang Huang, Ssu-Yuan Chen, Wei-Shiung Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Society of Sports Nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Observational
  5. Article
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  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Der-Sheng HanDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital BeiHu Branch, Taipei, Taiwan ; Community and Geriatric Medicine Research Center, National Taiwan University Hospital BeiHu Branch, Taipei, Taiwan ; Department of Athletic Training and Health, National Taiwan Sport University, TaoYuan, Taiwan ; Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Rd., Taipei, 100 Taiwan.
Chi-Huang HuangDepartment of Athletic Training and Health, National Taiwan Sport University, TaoYuan, Taiwan.
Ssu-Yuan ChenDepartment of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7, Chung-Shan South Rd., Taipei, Taiwan ; Department of Physical Medicine & Rehabilitation, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.
Wei-Shiung YangDepartment of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Rd., Taipei, 100 Taiwan ; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan ; Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan.
National Taiwan University Hospital · TWChung Shan Hospital · TWNational Taiwan Sport University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyostatin negatively regulates muscle growth, and its inhibition by suitable proteins can increase muscle bulk and exercise performance. However, the reference values of serum myostatin in athletes performing strength training are still lacking.

methodsA cross-sectional study recruiting28 male collegiate athletes performing strength training and 29 age-matched normal controls was conducted. The serum concentration of myostatin and insulin-like growth factor 1 (IGF-1), grip strength, and body composition were the main outcome measures. We used regression models to analyze the correlation between serum markers and the physiological parameters. The athlete group had greater height, weight, body mass index (BMI), fat mass percentage, fat-free mass, muscle mass, waist girth, grip strength, and estimated daily energy expenditure.

resultsThe IGF-1 concentration was higher in the athlete group (324 ± 80 vs. 263 ± 134 ng/ml), but the myostatin levels did not differ (12.1 ± 3.7 vs. 12.4 ± 3.5 ng/ml). The reference value for IGF-1 among the healthy young males was 293 ± 114 ng/ml, correlated with age and height; the value for myostatin was 12.3 ± 3.6 ng/ml, correlated negatively with BMI, fat mass percentage, and waist girth after adjustment for age.

conclusionMyostatin level is negatively related to fat percentage, and serum IGF-1 is positively related to height. The reference values could provide a basis for future doping-related study.

Indexed as

Doping in SportsResistance TrainingBiomarkersBody CompositionCross-Sectional StudiesHumansInsulin-Like Growth Factor IMaleMyostatinReference ValuesYoung AdultBiomarkersInsulin-Like Growth Factor IMyostatinBiomarkerDopingExerciseFat-free massReference value

Identifiers

PMID28077934
PMCPMC5223470
OpenAlexW2569100929

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.