SynthesisAging2017
The complex genetics of gait speed: genome-wide meta-analysis approach.
Erratum issuedOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed.GeroScience · 2018Pooled it
- DNA methylation signatures in skeletal muscle associated with physical function in healthy older adults.GeroScience · 2026Article
- GWAS of Active Music Engagement Frequency in the Canadian Longitudinal Study on Aging.Research square · 2026Article
- Multi-trait Genome-Wide Analysis Identified 20 Novel Loci for Sarcopenia-Related Traits in UK Biobank.Calcified tissue international · 2025Article
- Deep joint learning diagnosis of Alzheimer's disease based on multimodal feature fusion.BioData mining · 2024Article
- Adult Physical Function Has Roots in Early Childhood Brain Function: A Five-Decade Cohort Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
- Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Correlates of Gait Speed Among Older Adults From 6 Countries: Findings From the COSMIC Collaboration.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Proceedings of the Post-Genome Analysis for Musculoskeletal Biology Workshop.Current osteoporosis reports · 2023Review
- Article
- Construction of lncRNA-ceRNA Networks to Reveal the Potential Role of Lfng/Notch1 Signaling Pathway in Alzheimer's Disease.Current Alzheimer research · 2022Article
- Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty?Frontiers in cell and developmental biology · 2022Review
- Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults.Journal of the American Geriatrics Society · 2021Article
- Shifts in Gait Signatures Mark the End of Lifespan in Mice, With Sex Differences in Timing.Frontiers in aging neuroscience · 2021Article
- Footprints in the Sand: Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity.Frontiers in genetics · 2021Review
- Gait and balance disturbances are common in young urbanites and associated with cognitive impairment. Air pollution and the historical development of Alzheimer's disease in the young.Environmental research · 2020Article
- Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival.Communications biology · 2020Article
- Zebrafish models of sarcopenia.Disease models & mechanisms · 2020Review
- Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults.Ageing research reviews · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
70 authors at 20 institutions in 9 countries.
Dan Ben-AvrahamDepartment of Medicine and Genetics Albert Einstein College of Medicine, Bronx, NY 10461, USA.
David KarasikInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA.
Joe VergheseIntegrated Divisions of Cognitive & Motor Aging (Neurology) and Geriatrics (Medicine), Montefiore-Einstein Center for the Aging Brain, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kathryn L LunettaThe National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
John D EicherThe National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Rotem VeredPsychology Department, University of Haifa, Haifa, Israel.
Joris DeelenMolecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Alice M ArnoldDepartment of Biostatistics, University of Washington, Seattle, WA 98115, USA.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60614, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore MD 21224, USA.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA.
Maria NethanderBioinformatics Core Facility, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Myriam FornageThe University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Hieab H AdamsDepartment of Epidemiology, Erasmus MC, Rotterdam, Netherlands.
Amy M MatteiniDivision of Geriatric Medicine, Johns Hopkins Medical Institutes, Baltimore, MD 21224, USA.
Michele L CallisayaMedicine, Peninsula Health, Peninsula Clinical School, Central Clinical School, Frankston, Melbourne, Victoria, Australia.
Albert V SmithIcelandic Heart Association, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60614, USA.
Philip L De JagerBroad Institute of Harvard and MIT, Cambridge, Harvard Medical School, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Denis A EvansRush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Vilmundur GudnasonIcelandic Heart Association, Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
Albert HofmanDepartment of Epidemiology, Erasmus MC, Rotterdam, Netherlands.
Alison PattieDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Janie CorleyDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
Davis S KnopmanMayo Clinic, Rochester, MN 55905, USA.
Neeta ParimiCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94107, USA.
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Marian BeekmanMolecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Danielle GutmanDepartment of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel.
Lital SharvitDepartment of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel.
Simon P MooijaartGerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherland.
David C LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Jeanine J Houwing-DuistermaatGenetical Statistics, Leiden University Medical Center, Leiden, Netherland. Department of Statistics, University of Leeds, Leeds, UK.
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska, Academy, University of Gothenburg, Gothenburg, Sweden.
Matthijs MoedMolecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Vincent J VerlindenDepartment of Epidemiology, Erasmus MC, Rotterdam, Netherlands.
Dan MellströmDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska, Academy, University of Gothenburg, Gothenburg, Sweden.
Jos N van der GeestDepartment of Neuroscience, Erasmus MC, Rotterdam, Netherlands.
Magnus KarlssonClinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Dena HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Rebekah McWhirterMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Yongmei LiuDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC 27109, USA.
Russell ThomsonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Gregory J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94107, USA.
Andre G UitterlindenDepartment of Internal Medicine, Erasmus MC, and Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Andrew D JohnsonThe National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus MC, Rotterdam, Netherlands.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60614, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94107, USA.
Ian J DearyDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Thomas H MosleyUniversity of Mississippi Medical Center, Jackson, MS 39216, USA.
Velandai K SrikanthMedicine, Peninsula Health, Peninsula Clinical School, Central Clinical School, Frankston, Melbourne, Victoria, Australia.
Beverly G WindhamUniversity of Mississippi Medical Center, Jackson, MS 39216, USA.
Ann B NewmanDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Jeremy D WalstonDivision of Geriatric Medicine, Johns Hopkins Medical Institutes, Baltimore, MD 21224, USA.
Gail DaviesDepartment of Psychology, University of Edinburgh, Edinburgh, UK.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA 94107, USA.
Eline P SlagboomMolecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore MD 21224, USA.
Douglas P KielInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA.
Joanne M MurabitoThe National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Gil AtzmonDepartment of Medicine and Genetics Albert Einstein College of Medicine, Bronx, NY 10461, USA.
University of Edinburgh · GBUniversity of Michigan–Ann Arbor · USCalifornia Pacific Medical Center · USLeiden University Medical Center · NLNational Institute on Aging · USRush University Medical Center · USUniversity of Haifa · ILErasmus University Rotterdam · NLUniversity of Gothenburg · SEAlbert Einstein College of Medicine · USBeth Israel Deaconess Medical Center · USFramingham Heart Study · USJohns Hopkins University · USNational Heart Lung and Blood Institute · USPeninsula Health · AUUniversity of Iceland · ISUniversity of Tasmania · AUAzienda Sanitaria di Firenze · ITBroad Institute · USErasmus MC · NL
Funding
HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MOREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MCardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3MStudy of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MTHE PURPOSE OF MODIFICATION TO(1)INCREASE EFFORT OF OPTION 2 AND OPTION 3 FOR ICN01AG12100 · NIA · ICELANDIC HEART ASSOCIATION · PI GUDNASON, VILMUNDUR · 2007 to 2012
$18.4MBiotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council MR/K026992/1NCATS NIH HHS UL1 TR000124NCRR NIH HHS UL1 RR024140NCRR NIH HHS UL1 RR025005NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004402NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U10 HL054457NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR051124NIAMS NIH HHS RC2 AR058973NIAMS NIH HHS U01 AR045580NIAMS NIH HHS U01 AR045583NIAMS NIH HHS U01 AR045614NIAMS NIH HHS U01 AR045632NIAMS NIH HHS U01 AR045647NIAMS NIH HHS U01 AR045654NIA NIH HHS HHSN271201200022CNIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01AG12100NIA NIH HHS P30 AG010161NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG029451NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG023629NIA NIH HHS R56 AG029451NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS RF1 AG015819NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG018197NIA NIH HHS U01 AG027810NIA NIH HHS U24 AG051129NIDDK NIH HHS P30 DK063491NIMHD NIH HHS R01 MD009164NINDS NIH HHS R01 NS041558NINDS NIH HHS R01 NS078009
Abstract
Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and validated our results in 2,588 older adults from 4 independent studies. We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues. The meta-analysis resulted in a list of 536 suggestive genome wide significant SNPs in or near 69 genes. Further interrogation with Pathway Analysis placed gait speed as a polygenic complex trait in five major networks. Subsequent eQTL analysis revealed several SNPs significantly associated with the expression of PRSS16, WDSUB1 and PTPRT, which in addition to the meta-analysis and pathway suggested that genetic effects on gait speed may occur through synaptic function and neuronal development pathways. No genome-wide significant signals for gait speed were identified from this moderately large sample of older adults, suggesting that more refined physical function phenotypes will be needed to identify the genetic basis of gait speed in aging.
Indexed as
Polymorphism, Single NucleotideAgedAged, 80 and overAgingFemaleGaitGenome-Wide Association StudyHumansMaleMiddle AgedPhenotypeQuantitative Trait LociReceptor-Like Protein Tyrosine Phosphatases, Class 2Serine EndopeptidasesWalking SpeedPRSS16 protein, humanPTPRT protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 2Serine Endopeptidasesaginggait speedGWASmeta-analysis
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