Evidence map›Paper›PMID 28077781›Full record

ArticleAging2017

Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in

Gregory Tombline, Jonathan I Millen, Bogdan Polevoda, Matan Rapaport, Bonnie Baxter, Michael Van Meter, Matthew Gilbertson, Joe Madrey, Gary A Piazza, Lynn Rasmussen and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Yeast Tools for Studying Type II Topoisomerases in Budding Yeast.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Gregory TomblineBiology Department, University of Rochester, Rochester, NY 14627, USA.
Jonathan I MillenBiology Department, University of Rochester, Rochester, NY 14627, USA.
Bogdan PolevodaBiology Department, University of Rochester, Rochester, NY 14627, USA.
Matan RapaportBiology Department, University of Rochester, Rochester, NY 14627, USA.
Bonnie BaxterBiology Department, University of Rochester, Rochester, NY 14627, USA.
Michael Van MeterBiology Department, University of Rochester, Rochester, NY 14627, USA.
Matthew GilbertsonDepartment of Biopharmaceutical Sciences, UIC College of Pharmacy at Rockford, Rockford, IL 61107, USA.
Joe MadreyDrug Discovery Division, Southern Research Institute, Birmingham AL, 35205, USA.
Gary A PiazzaDrug Discovery Division, Southern Research Institute, Birmingham AL, 35205, USA.
Lynn RasmussenDrug Discovery Division, Southern Research Institute, Birmingham AL, 35205, USA.
Krister WennerbergDrug Discovery Division, Southern Research Institute, Birmingham AL, 35205, USA.
E Lucile WhiteDrug Discovery Division, Southern Research Institute, Birmingham AL, 35205, USA.
John L NitissDepartment of Biopharmaceutical Sciences, UIC College of Pharmacy at Rockford, Rockford, IL 61107, USA.
David S GoldfarbBiology Department, University of Rochester, Rochester, NY 14627, USA.
University of Rochester · USSouthern Research Institute · USUniversity of Illinois Chicago, Rockford campus · US

Funding

South Research Molecular Libraries Screening Center(RMI)U54HG003917 · NHGRI · SOUTHERN RESEARCH INSTITUTE · PI PIAZZA, GARY A · 2005 to 2008
$12.7M
ANTITOPOISOMERASE DRUG ACTION IN YEASTR01CA052814 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NITISS, JOHN L · 1990 to 2014
$2.7M
Molecular mechanisms which regulate SIRT6 activity and their relevance to agingF31AG041603 · NIA · UNIVERSITY OF ROCHESTER · PI VAN METER, MICHAEL JAMES · 2011 to 2014
$169k
Yeast Lifespan Chemical Screening (RMI)R03MH076395 · NIMH · UNIVERSITY OF ROCHESTER · PI GOLDFARB, DAVID S · 2005 to 2005
$5k
NCI NIH HHS R01 CA052814NHGRI NIH HHS U54 HG003917NIA NIH HHS F31 AG041603NIMH NIH HHS R03 MH076395
6 · The paper itself

Abstract

A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in

Indexed as

Cellular SenescenceDNA Breaks, Double-StrandedDNA DamageDNA Topoisomerases, Type IIGenomic InstabilityPoisonsSaccharomyces cerevisiaeTopoisomerase II InhibitorsDNA Topoisomerases, Type IIPoisonsTopoisomerase II Inhibitorsagingantagonistic pleiotropyDNA damagereplicative lifespantopoisomerase 2 poison

Identifiers

PMID28077781
PMCPMC5310657
OpenAlexW2571143476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.