ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Climbing Fibers Control Purkinje Cell Representations of Behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- CUSP: Complex spike sorting from multi-electrode array recordings with U-net sequence-to-sequence prediction.Journal of neuroscience methods · 2026Article
- CUSP: Complex Spike Sorting from Multi-electrode Array Recordings with U-net Sequence-to-Sequence Prediction.bioRxiv : the preprint server for biology · 2025Article
- Purkinje cells of the cerebellum control deceleration of tongue movements.PLoS biology · 2025Article
- Cerebellar control of targeted tongue movements.The Journal of physiology · 2025Article
- Control of tongue movements by the Purkinje cells of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- Cerebellar Functions Beyond Movement and Learning.Annual review of neuroscience · 2024Review
- The olivary input to the cerebellum dissociates sensory events from movement plans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Complex spikes perturb movements and reveal the sensorimotor map of Purkinje cells.Current biology : CB · 2023Article
- Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice.Communications biology · 2023Article
- Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human.Science (New York, N.Y.) · 2023Article
- Cerebellar associative learning underlies skilled reach adaptation.Nature neuroscience · 2023Article
- Cerebellar Representations of Errors and Internal Models.Cerebellum (London, England) · 2022Review
- Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor.International review of neurobiology · 2022Review
- Cerebellar complex spikes multiplex complementary behavioral information.PLoS biology · 2021Article
- Bidirectional learning in upbound and downbound microzones of the cerebellum.Nature reviews. Neuroscience · 2021Review
- Review
- Highlights from the 29th Annual Meeting of the Society for the Neural Control of Movement.Journal of neurophysiology · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A crucial issue in understanding cerebellar function is the interaction between simple spike (SS) and complex spike (CS) discharge, the two fundamentally different activity modalities of Purkinje cells. Although several hypotheses have provided insights into the interaction, none fully explains or is completely consistent with the spectrum of experimental observations. Here, we show that during a pseudo-random manual tracking task in the monkey (Macaca mulatta), climbing fiber discharge dynamically controls the information present in the SS firing, triggering robust and rapid changes in the SS encoding of motor signals in 67% of Purkinje cells. The changes in encoding, tightly coupled to CS occurrences, consist of either increases or decreases in the SS sensitivity to kinematics or position errors and are not due to differences in SS firing rates or variability. Nor are the changes in sensitivity due to CS rhythmicity. In addition, the CS-coupled changes in encoding are not evoked by changes in kinematics or position errors. Instead, CS discharge most often leads alterations in behavior. Increases in SS encoding of a kinematic parameter are associated with larger changes in that parameter than are decreases in SS encoding. Increases in SS encoding of position error are followed by and scale with decreases in error. The results suggest a novel function of CSs, in which climbing fiber input dynamically controls the state of Purkinje cell SS encoding in advance of changes in behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.