Evidence map›Paper›PMID 28077656›Full record

ArticleJournal of virology2017

Hierarchical and Redundant Roles of Activating FcγRs in Protection against Influenza Disease by M2e-Specific IgG1 and IgG2a Antibodies.

Silvie Van den Hoecke, Katrin Ehrhardt, Annasaheb Kolpe, Karim El Bakkouri, Lei Deng, Hendrik Grootaert, Steve Schoonooghe, Anouk Smet, Mostafa Bentahir, Kenny Roose and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 78 citations in OpenAlex.

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  17. A single-shot vaccine approach for the universal influenza A vaccine candidate M2e.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Silvie Van den HoeckeMedical Biotechnology Center, VIB, Ghent, Belgium.
Katrin EhrhardtInstitute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Annasaheb KolpeMedical Biotechnology Center, VIB, Ghent, Belgium.
Karim El BakkouriMedical Biotechnology Center, VIB, Ghent, Belgium.
Lei DengMedical Biotechnology Center, VIB, Ghent, Belgium.
Hendrik GrootaertMedical Biotechnology Center, VIB, Ghent, Belgium.
Steve SchoonoogheLaboratory of Myeloid Cell Immunology, VIB, Brussels, Belgium.
Anouk SmetMedical Biotechnology Center, VIB, Ghent, Belgium.
Mostafa BentahirMedical Biotechnology Center, VIB, Ghent, Belgium.
Kenny RooseMedical Biotechnology Center, VIB, Ghent, Belgium.
Michael SchotsaertMedical Biotechnology Center, VIB, Ghent, Belgium.
Bert SchepensMedical Biotechnology Center, VIB, Ghent, Belgium.
Nico CallewaertMedical Biotechnology Center, VIB, Ghent, Belgium.
Falk NimmerjahnDepartment of Biology, University of Erlangen-Nuremberg, Erlangen, Germany.
Peter StaeheliInstitute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Hartmut HengelInstitute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Xavier SaelensMedical Biotechnology Center, VIB, Ghent, Belgium xavier.saelens@vib-ugent.be.
Ghent University · BEVIB-UGent Center for Medical Biotechnology · BEUniversity of Freiburg · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ectodomain of matrix protein 2 is a universal influenza A virus vaccine candidate that provides protection through antibody-dependent effector mechanisms. Here we compared the functional engagement of Fcγ receptor (FcγR) family members by two M2e-specific monoclonal antibodies (MAbs), MAb 37 (IgG1) and MAb 65 (IgG2a), which recognize a similar epitope in M2e with similar affinities. The binding of MAb 65 to influenza A virus-infected cells triggered all three activating mouse Fcγ receptors

Indexed as

Adaptive ImmunityAnimalsAntibodies, MonoclonalAntibodies, ViralAntibody AffinityAntiviral AgentsCarbohydrate ConformationCarbohydrate SequenceGlycosylationHEK293 CellsHumansHybridomasImmunoglobulin GInfluenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesAntibodies, MonoclonalAntibodies, ViralAntiviral AgentsImmunoglobulin GInfluenza VaccinesM2 protein, Influenza A virusReceptors, IgGViral Matrix ProteinsViroporin ProteinsFcγ receptorsIgG antibody isotypeinfluenza A virusM2emechanism of protectionviral infection

Identifiers

PMID28077656
PMCPMC5355615
OpenAlexW2579771797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.