Evidence map›Paper›PMID 28077649›Full record

ArticleJournal of virology2017

T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.

Nina C Flerin, Huabiao Chen, Tynisha D Glover, Pedro A Lamothe, Jian Hua Zheng, Justin W Fang, Zaza M Ndhlovu, Evan W Newell, Mark M Davis, Bruce D Walker and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. CD8Nature reviews. Immunology · 2020
    Review
  5. T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Nina C FlerinDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Huabiao ChenRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Tynisha D GloverDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Pedro A LamotheRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Jian Hua ZhengDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Justin W FangRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Zaza M NdhlovuRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Evan W NewellAgency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN), Singapore.
Mark M DavisDepartment of Microbiology and Immunology, Stanford University, Stanford, California, USA.
Bruce D WalkerRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA bwalker@mgh.harvard.edu harris.goldstein@einstein.yu.edu.
Harris GoldsteinDepartment of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York, USA bwalker@mgh.harvard.edu harris.goldstein@einstein.yu.edu.
Albert Einstein College of Medicine · USRagon Institute of MGH, MIT and Harvard · USHarvard University · USHoward Hughes Medical Institute · USMassachusetts Institute of Technology · USStanford University · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Kathryn M. Anastos · 2017 to 2026
$28.3M
BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
Training in HIV/AIDS Pathogenesis; Basic and Translational ResearchT32AI007501 · NIAID · YESHIVA UNIVERSITY · PI PRASAD, VINAYAKA R. · 1995 to 2024
$6.6M
INHIBITION OF HIV1 REPLICATION BY CYTOTOXIC LYMPHOCYTESR01AI030914 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, BRUCE D · 1991 to 2013
$4.2M
Drugs of abuse and the epigenetic and signaling pathways controlling HIV latencyR01DA036171 · NIDA · CASE WESTERN RESERVE UNIVERSITY · PI GOLDSTEIN, HARRIS, HARVEY, BRANDON K · 2013 to 2017
$3.6M
Systems biology analysis of in vivo impact of substance abuse on HIV infectionR01DA033788 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GOLDSTEIN, HARRIS · 2012 to 2016
$3.0M
Howard Hughes Medical InstituteNIAID NIH HHS P30 AI060354NIAID NIH HHS P30 AI124414NIAID NIH HHS R01 AI030914NIAID NIH HHS T32 AI007501NIAID NIH HHS UM1 AI126617NIDA NIH HHS R01 DA033788NIDA NIH HHS R01 DA036171
6 · The paper itself

Abstract

Functional analysis of T-cell responses in HIV-infected individuals has indicated that virus-specific CD8

Indexed as

Cells, CulturedCloning, MolecularEpitopes, T-LymphocyteGene ExpressionHIV-1HumansReceptors, Antigen, T-CellT-Lymphocytes, CytotoxicEpitopes, T-LymphocyteReceptors, Antigen, T-CellclonotypeHIVT cellsTCR

Identifiers

PMID28077649
PMCPMC5331796
OpenAlexW2577894088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.