Evidence map›Paper›PMID 28077642›Full record

ArticleJournal of virology2017

Studies on the Interaction of Tumor-Derived HD5 Alpha Defensins with Adenoviruses and Implications for Oncolytic Adenovirus Therapy.

Charles Vragniau, Jens-Martin Hübner, Peter Beidler, Sucheol Gil, Kamola Saydaminova, Zhuo-Zhuang Lu, Roma Yumul, Hongjie Wang, Maximilian Richter, Pavel Sova and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Roles of Antimicrobial Peptides in Gynecological Cancers.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Review
  10. Antiviral Activities of Human Host Defense Peptides.Current medicinal chemistry · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Charles VragniauDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Jens-Martin HübnerDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Peter BeidlerDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Sucheol GilDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Kamola SaydaminovaDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Zhuo-Zhuang LuDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Roma YumulDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Hongjie WangDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Maximilian RichterDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Pavel SovaDivision of Medical Genetics, University of Washington, Seattle, Washington, USA.
Charles DrescherFred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Pascal FenderInstitut de Biologie Structurale, CNRS/UGA/CEA, Grenoble, France.
André LieberDivision of Medical Genetics, University of Washington, Seattle, Washington, USA lieber00@uw.edu.
University of Washington Medical Center · USCentre National de la Recherche Scientifique · FRFred Hutch Cancer Center · USUniversity of Washington · US

Funding

Vaccinating against IGFBP-2 to prevent ovarian cancer relapseP50CA083636 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DRESCHER, CHARLES, URBAN, NICOLE DENISE · 1999 to 2015
$35.1M
NCI NIH HHS P50 CA083636
6 · The paper itself

Abstract

Defensins are small antimicrobial peptides capable of neutralizing human adenovirus (HAdV)

Indexed as

Immune EvasionOncolytic VirotherapyAdenoviruses, Humanalpha-DefensinsBiopsyCaco-2 CellsEpithelial CellsFemaleHumansLung NeoplasmsOncolytic VirusesOvarian Neoplasmsalpha-DefensinsDEFA5 protein, humanadenoviruscancerdefensinsinnate immunity

Identifiers

PMID28077642
PMCPMC5331826
OpenAlexW2575872007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.