ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Two-Phase Hospital-Associated Outbreak of Mycobacterium abscessus: Investigation and Mitigation.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Water Management for Construction: Evidence for Risk Characterization in Community and Healthcare Settings: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Systematic Review and Meta-analyses of the Effect of Chemotherapy on Pulmonary Mycobacterium abscessus Outcomes and Disease Recurrence.Antimicrobial agents and chemotherapy · 2017Pooled it
- Investigation of Mycobacterium abscessus Cluster in Hospital, Maryland, USA, 2024.Emerging infectious diseases · 2026Review
- Hospital Environment-Associated Sources of Mycobacterium abscessus Infection in Transplant Recipients.JAMA network open · 2026Article
- Epidemiology of Healthcare Facility-Associated Nontuberculous Mycobacteria From 2012 Through 2020 in a 10-Hospital Network in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- A cross-environment comparison of nontuberculous mycobacterial diversity.Applied and environmental microbiology · 2026Article
- Society for Healthcare Epidemiology of America supports environmental stewardship and sustainability while protecting patients and healthcare personnel position statement of the SHEA Board.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Biofilm formation by the global outbreak strain of Mycobacterium chimaera results in significantly reduced efficacy of standard disinfectants.BMC microbiology · 2025Article
- The role of colony morphotype in shaping gene essentiality inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Infection by Clonally RelatedAmerican journal of respiratory and critical care medicine · 2025Article
- Mutations in the transcriptional regulator MAB_2885 confer tedizolid and linezolid resistance through the MmpS-MmpL efflux pump MAB_2302-MAB_2303 in Mycobacterium abscessus.PLoS pathogens · 2025Article
- Extrapulmonary Mycobacterium abscessus Infections, France, 2012-2020Emerging infectious diseases · 2024Article
- Sanitary Waters: Is It Worth Looking for Mycobacteria?Microorganisms · 2024Article
- Genomic epidemiology ofERJ open research · 2024Article
- Article
- A cluster of three extrapulmonaryInfection control and hospital epidemiology · 2024Article
- Risk Factors for and Outcomes Following Early Acquisition ofOpen forum infectious diseases · 2024Article
- Therapy ofMicroorganisms · 2024Review
- Exploring antibiotic resistance mechanisms inFrontiers in microbiology · 2024Review
- Benign disorders of the mediastinum: a narrative review.Mediastinum (Hong Kong, China) · 2024Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
28 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNontuberculous mycobacteria (NTM) commonly colonize municipal water supplies and cause healthcare-associated outbreaks. We investigated a biphasic outbreak of Mycobacterium abscessus at a tertiary care hospital.
methodsCase patients had recent hospital exposure and laboratory-confirmed colonization or infection with M. abscessus from January 2013 through December 2015. We conducted a multidisciplinary epidemiologic, field, and laboratory investigation.
resultsThe incidence rate of M. abscessus increased from 0.7 cases per 10000 patient-days during the baseline period (January 2013-July 2013) to 3.0 cases per 10000 patient-days during phase 1 of the outbreak (August 2013-May 2014) (incidence rate ratio, 4.6 [95% confidence interval, 2.3-8.8]; P < .001). Thirty-six of 71 (51%) phase 1 cases were lung transplant patients with positive respiratory cultures. We eliminated tap water exposure to the aerodigestive tract among high-risk patients, and the incidence rate decreased to baseline. Twelve of 24 (50%) phase 2 (December 2014-June 2015) cases occurred in cardiac surgery patients with invasive infections. Phase 2 resolved after we implemented an intensified disinfection protocol and used sterile water for heater-cooler units of cardiopulmonary bypass machines. Molecular fingerprinting of clinical isolates identified 2 clonal strains of M. abscessus; 1 clone was isolated from water sources at a new hospital addition. We made several water engineering interventions to improve water flow and increase disinfectant levels.
conclusionsWe investigated and mitigated a 2-phase clonal outbreak of M. abscessus linked to hospital tap water. Healthcare facilities with endemic NTM should consider similar tap water avoidance and engineering strategies to decrease risk of NTM infection.
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