ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Early-Onset Invasive Candidiasis in Extremely Low Birth Weight Infants: Perinatal Acquisition Predicts Poor Outcome.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 46 citations in OpenAlex.
- Infection-Related Preterm Birth.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Review
- The Role of Lactoferrin in CombatingMolecules (Basel, Switzerland) · 2025Review
- Addressing the silent threat: managing invasiveFrontiers in pediatrics · 2025Review
- Congenital Sepsis withMicroorganisms · 2024Review
- Rare case of early neonatal sepsis caused byMedical mycology case reports · 2024Article
- It's time to shed some light on the importance of fungi in neonatal intensive care units: what do we know about the neonatal mycobiome?Frontiers in microbiology · 2024Review
- Congenital candidiasis in a full-term infant: A case report.The Journal of international medical research · 2023Article
- Epidemiology and associated risk factors for candidemia in a Canadian tertiary paediatric hospital: An 11-year review.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2023Article
- Vulvovaginal yeast infections, gestational diabetes and pregnancy outcome.BMC pregnancy and childbirth · 2023Article
- Ameliorating adverse perinatal outcomes with Lactoferrin: An intriguing chemotherapeutic intervention.Bioorganic & medicinal chemistry · 2022Review
- Wor1-regulated ferroxidases contribute to pigment formation in opaque cells of Candida albicans.FEBS open bio · 2021Article
- Review
- Role of Maternal Infections and Inflammatory Responses on Craniofacial Development.Frontiers in oral health · 2021Review
- Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β-catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide.Brain pathology (Zurich, Switzerland) · 2020Article
- Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.Frontiers in immunology · 2020Review
- Candida pneumonia with severe clinical course, recovery with antifungal therapy and unusual pathologic findings: A case report.Medicine · 2018Article
- Epidemiology of Invasive Fungal Disease in Children.Journal of the Pediatric Infectious Diseases Society · 2017Review
- Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.Journal of the Pediatric Infectious Diseases Society · 2017Review
- Invasive Candidiasis in Very Premature Neonates: Tiny Tots With Big Problems.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
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19 authors at 16 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeonatal invasive candidiasis (IC) presenting in the first week of life is less common and less well described than later-onset IC. Risk factors, clinical features, and disease outcomes have not been studied in early-onset disease (EOD, ≤7 days) or compared to late-onset disease (LOD, >7 days).
methodsAll extremely low birth weight (ELBW, <1000 g) cases with IC and controls from a multicenter study of neonatal candidiasis enrolled from 2001 to 2003 were included in this study. Factors associated with occurrence and outcome of EOD in ELBW infants were determined.
resultsForty-five ELBW infants and their 84 matched controls were included. Fourteen (31%) ELBW infants had EOD. Birth weight <750 g, gestation <25 weeks, chorioamnionitis, and vaginal delivery were all strongly associated with EOD. Infection with Candida albicans, disseminated disease, pneumonia, and cardiovascular disease were significantly more common in EOD than in LOD. The EOD case fatality rate (71%) was higher than in LOD (32%) or controls (15%) (P = .0001). The rate of neurodevelopmental impairment and mortality combined was similar in EOD (86%) and LOD (72%), but higher than in controls (32%; P = .007).
conclusionsELBW infants with EOD have a very poor prognosis compared to those with LOD. The role of perinatal transmission in EOD is supported by its association with chorioamnionitis, vaginal delivery, and pneumonia. Dissemination and cardiovascular involvement are common, and affected infants often die. Empiric treatment should be considered for ELBW infants delivered vaginally who have pneumonia and whose mothers have chorioamnionitis or an intrauterine foreign body.
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