Evidence map›Paper›PMID 28077441›Full record

ArticleClinical and vaccine immunology : CVI2017

Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods.

Sophie J Rhodes, Charlotte Sarfas, Gwenan M Knight, Andrew White, Ansar A Pathan, Helen McShane, Thomas G Evans, Helen Fletcher, Sally Sharpe, Richard G White

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Review
  4. Review
  5. Review
  6. The Legacy of CVI.Clinical and vaccine immunology : CVI · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sophie J RhodesTB Modelling Group, CMMID, TB Centre, London School of Hygiene and Tropical Medicine, London, United Kingdom Sophie.rhodes@lshtm.ac.uk.
Charlotte SarfasPublic Health England, Porton Down, United Kingdom.
Gwenan M KnightTB Modelling Group, CMMID, TB Centre, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Andrew WhitePublic Health England, Porton Down, United Kingdom.
Ansar A PathanCollege of Health and Life Sciences, Department of Life Sciences, Brunel University, London, United Kingdom.
Helen McShaneThe Jenner Institute, University of Oxford, Oxford, United Kingdom.
Thomas G EvansTomegaVax, Portland, Oregon, USA.
Helen FletcherImmunology and Infection Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID http://orcid.org/0000-0002-0435-1006
Sally SharpePublic Health England, Porton Down, United Kingdom.
Richard G WhiteTB Modelling Group, CMMID, TB Centre, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Public Health England · GBUniversity of London · GBBrunel University of London · GBLondon School of Hygiene & Tropical Medicine · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/P002404/1
6 · The paper itself

Abstract

Macaques play a central role in the development of human tuberculosis (TB) vaccines. Immune and challenge responses differ across macaque and human subpopulations. We used novel immunostimulation/immunodynamic modeling methods in a proof-of-concept study to determine which macaque subpopulations best predicted immune responses in different human subpopulations. Data on gamma interferon (IFN-γ)-secreting CD4

Indexed as

Healthy VolunteersAdolescentAdultAnimalsBCG VaccineCD4-Positive T-LymphocytesChildChild, PreschoolDrug DiscoveryFemaleHumansInfantInterferon-gammaMacacaMaleMiddle AgedBCG VaccineInterferon-gammabacillus Calmette-Guérininterferonsmathematical modelingnonhuman primatesT-cell immunitytuberculosistuberculosis vaccines

Identifiers

PMID28077441
PMCPMC5339646
OpenAlexW2575473571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.