ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Candidate Mechanisms of Cerebral Ischemia/Hypoxia Tolerance: Insights from Hibernating Rodents.Neurochemical research · 2026Review
- Nature's fat-burning machine: brown adipose tissue in a hibernating mammal.The Journal of experimental biology · 2018Review
- Effects of cold on murine brain mitochondrial function.PloS one · 2018Article
- Water-fat MRI in a hibernator reveals seasonal growth of white and brown adipose tissue without cold exposure.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Although seasonal modifications of brown adipose tissue (BAT) in hibernators are well documented, we know little about functional regulation of BAT in different phases of hibernation. In the 13-lined ground squirrel, liver mitochondrial respiration is suppressed by up to 70% during torpor. This suppression is reversed during arousal and interbout euthermia (IBE), and corresponds with patterns of maximal activities of electron transport system (ETS) enzymes. Uncoupling of BAT mitochondria is controlled by free fatty acid release stimulated by sympathetic activation of adipocytes, so we hypothesized that further regulation at the level of the ETS would be of little advantage. As predicted, maximal ETS enzyme activities of isolated BAT mitochondria did not differ between torpor and IBE. In contrast to this pattern, respiration rates of mitochondria isolated from torpid individuals were suppressed by ~60% compared with rates from IBE individuals when measured at 37°C. At 10°C, however, mitochondrial respiration rates tended to be greater in torpor than IBE. As a result, the temperature sensitivity (Q
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Registered trials
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