Evidence map›Paper›PMID 28077374›Full record

ArticleAmerican journal of physiology. Renal physiology2017

Parallel microarray profiling identifies ErbB4 as a determinant of cyst growth in ADPKD and a prognostic biomarker for disease progression.

Andrew J Streets, Tajdida A Magayr, Linghong Huang, Laura Vergoz, Sandro Rossetti, Roslyn J Simms, Peter C Harris, Dorien J M Peters, Albert C M Ong

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  6. MicroRNAs in kidney injury and disease.Nature reviews. Nephrology · 2022
    Review
  7. Review
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  9. Non-Coding RNAs in Hereditary Kidney Disorders.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Review
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  16. Article
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  18. Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Andrew J StreetsKidney Genetics Group, Academic Unit of Nephrology, The Medical School, University of Sheffield, United Kingdom; a.j.streets@sheffield.ac.uk.
Tajdida A MagayrKidney Genetics Group, Academic Unit of Nephrology, The Medical School, University of Sheffield, United Kingdom.
Linghong HuangKidney Genetics Group, Academic Unit of Nephrology, The Medical School, University of Sheffield, United Kingdom.
Laura VergozKidney Genetics Group, Academic Unit of Nephrology, The Medical School, University of Sheffield, United Kingdom.
Sandro RossettiDivision of Nephrology, Mayo Clinic and Foundation, Rochester, Minnesota; and.
Roslyn J SimmsKidney Genetics Group, Academic Unit of Nephrology, The Medical School, University of Sheffield, United Kingdom.
Peter C HarrisDivision of Nephrology, Mayo Clinic and Foundation, Rochester, Minnesota; and.
Dorien J M PetersDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Albert C M OngKidney Genetics Group, Academic Unit of Nephrology, The Medical School, University of Sheffield, United Kingdom.
University of Sheffield · GBMayo Clinic · USLeiden University Medical Center · NL

Funding

Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI TORRES, VICENTE E · 2010 to 2019
$11.8M
NIDDK NIH HHS P30 DK090728
6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the fourth most common cause of end-stage renal disease. The disease course can be highly variable and treatment options are limited. To identify new therapeutic targets and prognostic biomarkers of disease, we conducted parallel discovery microarray profiling in normal and diseased human

Indexed as

Cell ProliferationOligonucleotide Array Sequence AnalysisAnimalsCase-Control StudiesDisease Models, AnimalDisease ProgressionGene Expression ProfilingGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseHEK293 CellsHumansKidneyMice, KnockoutMicroRNAsMutationERBB4 protein, humanErbb4 protein, mouseGenetic MarkersMicroRNAsMIRN193 microRNA, humanNeuregulin-1Receptor, ErbB-4TRPP Cation ChannelsADPKDErbB4 microRNApolycystin

Identifiers

PMID28077374
PMCPMC5504395
OpenAlexW2573699273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.