Evidence map›Paper›PMID 28077136›Full record

ArticleLipids in health and disease2017

Increased leptin/adiponectin ratio relates to low-normal thyroid function in metabolic syndrome.

Lynnda J N van Tienhoven-Wind, Robin P F Dullaart

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Obesity and Thyroid Axis.International journal of environmental research and public health · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lynnda J N van Tienhoven-WindDepartment of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. L.J.N.van.Tienhoven-Wind@umcg.nl.
Robin P F DullaartDepartment of Endocrinology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown.

methodsRelationships of thyroid stimulating hormone (TSH) and free thyroxine (free T

resultsNeither plasma leptin nor adiponectin was significantly correlated with TSH or free T

conclusionsIn the context of MetS, a higher TSH within the euthyroid range confers an increased L/A ratio, a proposed marker of atherosclerosis susceptibility and adipocyte dysfunction.

Indexed as

AdipocytesAdiponectinAdipose TissueAgedAntihypertensive AgentsAtherosclerosisC-Reactive ProteinCross-Sectional StudiesFastingFemaleGene Expression RegulationGenetic Predisposition to DiseaseHumansHypoglycemic AgentsLeptinMaleAdiponectinADIPOQ protein, humanAntihypertensive AgentsC-Reactive ProteinHypoglycemic AgentsLeptinThyrotropinThyroxineAdiponectinLeptinLeptin/adiponectin ratioMetabolic syndromeThyroid function

Identifiers

PMID28077136
PMCPMC5225648
OpenAlexW2578996790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.