ArticleBMC pulmonary medicine2017
Recurrent pneumonia among Japanese adults: disease burden and risk factors.
Article in BMC pulmonary medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Factors driving outcome variability in aspiration and community-acquired pneumonia: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Comparison of infection risks and clinical outcomes in patients with and without SARS-CoV-2 lung infection under renin-angiotensin-aldosterone system blockade: Systematic review and meta-analysis.British journal of clinical pharmacology · 2021Pooled it
- Effect of tobacco smoking on the risk of developing community acquired pneumonia: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Reducing the complications from community acquired pneumonia: a review.Journal of thoracic disease · 2026Review
- Risk factors for community-acquired pneumonia in older adults in Japan after the introduction of the childhood PCV13.BMC infectious diseases · 2026Article
- Long-term economic value analysis of reducing postoperative air leak following lung resection.Journal of thoracic disease · 2026Article
- Article
- Advantages of short-term antimicrobial treatment for pneumonia and aspiration pneumonia in older patients aged over 65: A nationwide inpatient database study.Global health & medicine · 2025Article
- Advances in Understanding Recurrent Pulmonary Infections Following Foreign Body Aspiration: A Narrative Review.Journal of asthma and allergy · 2025Review
- Risk factors and interventions for developing recurrent pneumonia in older adults.ERJ open research · 2023Article
- Hypnotics and injuries among older adults with Parkinson's disease: a nested case-control design.BMC geriatrics · 2023Article
- Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota.Advances in nutrition (Bethesda, Md.) · 2022Review
- Comparison of respiratory function, physical function, and activities of daily living among community-dwelling patients with respiratory and non-respiratory disease.Journal of physical therapy science · 2022Article
- Real-world effectiveness of early intervention with fixed-dose tiotropium/olodaterol vs tiotropium in Japanese patients with COPD: a high-dimensional propensity score-matched cohort analysis.Respiratory research · 2021Article
- Characteristic Factors of Aspiration Pneumonia to Distinguish from Community-Acquired Pneumonia among Oldest-Old Patients in Primary-Care Settings of Japan.Geriatrics (Basel, Switzerland) · 2020Article
- Risk factors analysis of nosocomial pneumonia in elderly patients with acute cerebral infraction.Medicine · 2019Article
- Article
- Impact of the number of aspiration risk factors on mortality and recurrence in community-onset pneumonia.Clinical interventions in aging · 2017Article
- Percutaneous endoscopic gastrostomy feeding effects in patients with neurogenic dysphagia and recurrent pneumonia.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Japan and other societies with rapidly aging populations, recurrent pneumonia (RP) is a major clinical problem yet only limited information exists regarding the burden of this disease.
methodsA prospective study of adult pneumonia was conducted to investigate the incidence of RP and potential risk factors. From February 1, 2012 to January 31, 2013, patients aged ≥ 15 years who were diagnosed with pneumonia were prospectively enrolled in a representative community hospital located in central Japan. Patients were followed for one-year to evaluate the recurrence of pneumonia and characteristics associated with RP. Cox proportional hazards models were constructed to compute adjusted hazard ratios (aHR) and ascertain risk factors significantly associated with RP.
resultsIn total, 841 patients with a median age of 73 years (range 15-101 years) were enrolled totaling 1,048 person-years of observation with a median follow-up time of 475 days. A total of 137 patients had at least one recurrent episode with an incidence rate of 13.1 per 100 person-years (95% confidence interval: 11.1-15.5). In multivariate analysis, a past history of pneumonia (aHR 1.95, 95% CI: 1.35-2.8), chronic pulmonary disease (aHR 1.86, 1.24-2.78) and inhaled corticosteroid usage (aHR 1.78, 1.12-2.84) and hypnotic/sedative medication usage (aHR 2.06, 1.28-3.31) were identified as independent risk factors for recurrent pneumonia, whereas angiotensin converting enzyme-inhibitors usage was associated with a reduction of the risk of RP (aHR 0.22, 0.05-0.91). The detection of P. aeruginosa was significantly associated with RP even after adjusting for chronic pulmonary diseases (aHR = 2.37).
conclusionsRecurrent pneumonia constitutes a considerable proportion of the pneumonia burden in Japan. A past history of pneumonia, chronic pulmonary disease, inhaled corticosteroid and hypnotic/sedative medication usage and detection of P. aeruginosa were identified as independent risk factors for recurrent pneumonia and special attention regarding the use of medications in this vulnerable population is needed to reduce the impact of this disease in aging populations.
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