ArticleBMC plant biology2017
The Arabidopsis paralogs, PUB46 and PUB48, encoding U-box E3 ubiquitin ligases, are essential for plant response to drought stress.
Article in BMC plant biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- A GWAS-identified U-box E3 ligase MsPUB6 is positively regulated by MsDREB1C and contributes to drought tolerance in alfalfa.Plant physiology · 2026Article
- Salicylic acid reduces MdPUB24-mediated ubiquitination of MdWRKY40 to suppress ethylene biosynthesis in apple fruit.Horticulture research · 2026Article
- Transcriptomic and physiological effects of superabsorbent polymer seed coating on maize under drought stress.Frontiers in plant science · 2026Article
- MpPUB9, a U-box E3 ubiquitin ligase, acts as a positive regulator by promoting the turnover of MpEXO70.1 under high salinity in Marchantia polymorpha.The New phytologist · 2024Article
- Arabidopsis ubiquitin ligase PUB41 positively regulates ABA-mediated seed dormancy and drought response.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance.Plant biotechnology journal · 2024Review
- Active protein ubiquitination regulates xylem vessel functionality.The Plant cell · 2024Article
- Genome-wide analysis of the U-box E3 ligases gene family in potato (Solanum tuberosum L.) and overexpress StPUB25 enhance drought tolerance in transgenic Arabidopsis.BMC genomics · 2024Article
- Genome-wide identification and expression analysis of the U-box E3 ubiquitin ligase gene family related to bacterial wilt resistance in tobacco (Frontiers in plant science · 2024Article
- Genome-wide identification ofFrontiers in genetics · 2024Article
- The activity of the stress modulated Arabidopsis ubiquitin ligases PUB46 and PUB48 is partially redundant.Plant signaling & behavior · 2022Article
- The E3 Ligase GmPUB21 Negatively Regulates Drought and Salinity Stress Response in Soybean.International journal of molecular sciences · 2022Article
- Review
- Apple U-box-type E3 ubiquitin ligase MdPUB23 reduces cold-stress tolerance by degrading the cold-stress regulatory protein MdICE1.Horticulture research · 2022Article
- Molecular Characterization of U-box E3 Ubiquitin Ligases (TaPUB2 and TaPUB3) Involved in the Positive Regulation of Drought Stress Response inInternational journal of molecular sciences · 2021Article
- Identification and expression analysis ofPlant signaling & behavior · 2021Article
- The U-box E3 ubiquitin ligase PalPUB79 positively regulates ABA-dependent drought tolerance via ubiquitination of PalWRKY77 in Populus.Plant biotechnology journal · 2021Article
- Molecular and Functional Analysis of U-box E3 Ubiquitin Ligase Gene Family in Rice (International journal of molecular sciences · 2021Article
- Genome-wide identification and functional analysis of U-box E3 ubiquitin ligases gene family related to drought stress response in Chinese white pear (Pyrus bretschneideri).BMC plant biology · 2021Article
- Genome Wide Analysis of U-Box E3 Ubiquitin Ligases in Wheat (International journal of molecular sciences · 2021Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundPlants respond to abiotic stress on physiological, biochemical and molecular levels. This includes a global change in their cellular proteome achieved by changes in the pattern of their protein synthesis and degradation. The ubiquitin-proteasome system (UPS) is a key player in protein degradation in eukaryotes. Proteins are marked for degradation by the proteasome by coupling short chains of ubiquitin polypeptides in a three-step pathway. The last and regulatory stage is catalyzed by a member of a large family of substrate-specific ubiquitin ligases.
resultsWe have identified AtPUB46 and AtPUB48-two paralogous genes that encode ubiquitin ligases (E3s)-to have a role in the plant environmental response. The AtPUB46, -47, and -48 appear as tandem gene copies on chromosome 5, and we present a phylogenetic analysis that traces their evolution from an ancestral PUB-ARM gene. Single homozygous T-DNA insertion mutants of AtPUB46 and AtPUB48 displayed hypersensitivity to water stress; this was not observed for similar mutants of AtPUB47. Although the three genes show a similar spatial expression pattern, the steady state levels of their transcripts are differentially affected by abiotic stresses and plant hormones.
conclusionsAtPUB46 and AtPUB48 encode plant U-Box E3s and are involved in the response to water stress. Our data suggest that despite encoding highly homologous proteins, AtPUB46 and AtPUB48 biological activity does not fully overlap.
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