Evidence map›Paper›PMID 28076935›Full record

ArticleEuropean journal of histochemistry : EJH2016

High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling.

G Tossetta, C Avellini, C Licini, S R Giannubilo, M Castellucci, D Marzioni

Open access · goldAbstract read
In one paragraph

Article in European journal of histochemistry : EJH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 33 citations in OpenAlex.

  1. Importance of STAT3 signaling in preeclampsia (Review).International journal of molecular medicine · 2025
    Review
  2. Multi-omic studies on the pathogenesis of Sepsis.Journal of translational medicine · 2025
    Article
  3. Article
  4. Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Vascular Extracellular Matrix in Atherosclerosis.International journal of molecular sciences · 2024
    Review
  8. Article
  9. Article
  10. First Trimester Placental Biomarkers for Pregnancy Outcomes.International journal of molecular sciences · 2024
    Review
  11. Special Issue "Physiology and Pathophysiology of Placenta 2.0".International journal of molecular sciences · 2024
    Article
  12. Special Issue "Physiology and Pathophysiology of the Placenta".International journal of molecular sciences · 2024
    Article
  13. Article
  14. Review
  15. Circulating miRNAs and Preeclampsia: From Implantation to Epigenetics.International journal of molecular sciences · 2024
    Review
  16. Review
  17. Review
  18. Physiology and Pathophysiology of the Placenta.International journal of molecular sciences · 2023
    Article
  19. Article
  20. HTRA1 in Placental Cell Models: A Possible Role in Preeclampsia.Current issues in molecular biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

G TossettaPolytechnic University of Marche, Department of Experimental and Clinical Medicine. g.tossetta@univpm.it.
C Avellini
C Licini
S R Giannubilo
M Castellucci
D Marzioni
Marche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High temperature requirement A1 (HtrA1) is a secreted protease involved in placental development. Fibronectin (FN) is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta such as mesenchymal villi as well as cell islands and cell columns. We demonstrated that FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation.

Indexed as

Chorionic VilliFemaleFibronectinsGene Expression RegulationHigh-Temperature Requirement A Serine Peptidase 1HumansPregnancySerine EndopeptidasesFibronectinsHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanSerine Endopeptidases

Identifiers

PMID28076935
PMCPMC5134679
OpenAlexW2555168928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.