Evidence map›Paper›PMID 28076809›Full record

ArticleBiophysical journal2017

A Model for the Transient Subdiffusive Behavior of Particles in Mucus.

Matthias Ernst, Thomas John, Marco Guenther, Christian Wagner, Ulrich F Schaefer, Claus-Michael Lehr

Abstract read
In one paragraph

Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Transport in the Brain Extracellular Space: Diffusion, but Which Kind?International journal of molecular sciences · 2022
    Review
  8. Article
  9. Negative friction memory induces persistent motion.The European physical journal. E, Soft matter · 2020
    Article
  10. Review
  11. Article
  12. Article
  13. Photoactivatable fluorescent probes reveal heterogeneous nanoparticle permeation through biological gels at multiple scales.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthias ErnstFaculty of Engineering, Department of Applied Mathematics, University of Applied Sciences, Saarbrücken, Germany.
Thomas JohnDepartment of Experimental Physics, Saarland University, Saarbrücken, Germany.
Marco GuentherFaculty of Engineering, Department of Applied Mathematics, University of Applied Sciences, Saarbrücken, Germany.
Christian WagnerDepartment of Experimental Physics, Saarland University, Saarbrücken, Germany; Physics and Materials Science Research Unit, University of Luxembourg, Luxembourg, Luxembourg.
Ulrich F SchaeferDepartment of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbrücken, Germany.
Claus-Michael LehrDepartment of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbrücken, Germany; Helmholtz Institute for Pharmaceutical Research Saarland, Saarland University, Saarbrücken, Germany. Electronic address: Claus-Michael.Lehr@helmholtz-hzi.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study we have applied a model to explain the reported subdiffusion of particles in mucus, based on the measured mean squared displacements (MSD). The model considers Brownian diffusion of particles in a confined geometry, made from permeable membranes. The applied model predicts a normal diffusive behavior at very short and long time lags, as observed in several experiments. In between these timescales, we find that the "subdiffusive" regime is only a transient effect, MSD∝τ

Indexed as

Models, BiologicalMovementCystic FibrosisDiffusionHumansLungMucusNanoparticlesPolyethylene GlycolsSputumPolyethylene Glycols

Identifiers

PMID28076809
PMCPMC5233549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.