Evidence map›Paper›PMID 28076620›Full record

ArticleBrazilian journal of cardiovascular surgery

Intraperitoneal Administration of Silymarin Protects End Organs from Multivisceral Ischemia/Reperfusion Injury in a Rat Model.

Aydemir Koçarslan, Sezen Koçarslan, Mehmet Salih Aydin, Şamil Gunay, Mahmut Alp Karahan, Abdullah Taşkın, Murat Üstunel, Nurten Aksoy

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of cardiovascular surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aydemir KoçarslanKahramanmaraş Sütçü Imam University, Faculty of Medicine, Department of Cardiovascular Surgery, Kahramanmaraş, Turkey.
Sezen KoçarslanKahramanmaraş Sütçü Imam University, Faculty of Medicine, Department of Pathology, Kahramanmaraş, Turkey.
Mehmet Salih AydinHarran University, Faculty of Medicine, Department of Cardiovascular Surgery, Sanliurfa, Turkey.
Şamil GunayHarran University, Faculty of Medicine, Department of Thoracic Surgery, Sanliurfa, Turkey.
Mahmut Alp KarahanHarran University, Faculty of Medicine, Department of Anesthesia and Reanimation, Sanliurfa, Turkey.
Abdullah TaşkınHarran University, Faculty of Medicine, Department of Biochemistry, Sanliurfa, Turkey.
Murat ÜstunelŞanlıurfa Maternity Hospital, Department of Biochemistry, Sanliurfa, Turkey.
Nurten AksoyHarran University, Faculty of Medicine, Department of Biochemistry, Sanliurfa, Turkey.
Harran University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine whether intraperitoneal silymarin administration has favorable effects on the heart, lungs, kidney, and liver and on oxidative stress in a rat model of supraceliac aorta ischemia/reperfusion injury. Methods: Thirty male Wistar albino rats were divided equally into three groups: sham, control, and silymarin. The control and silymarin groups underwent supraceliac aortic occlusion for 45 min, followed by a 60 min period of reperfusion under terminal anesthesia. In the silymarin group, silymarin was administered intraperitoneally during ischemia at a dose of 200 mg/kg. Rats were euthanized using terminal anesthesia, and blood was collected from the inferior vena cava for total antioxidant capacity, total oxidative status, and oxidative stress index measurement. Lungs, heart, liver and kidney tissues were histologically examined. Results: Ischemia/reperfusion injury significantly increased histopathological damage as well as the total oxidative status and oxidative stress index levels in the blood samples. The silymarin group incurred significantly lesser damage to the lungs, liver and kidneys than the control group, while no differences were observed in the myocardium. Furthermore, the silymarin group had significantly lower total oxidative status and oxidative stress index levels than the control group. Conclusion: Intraperitoneal administration of silymarin reduces oxidative stress and protects the liver, kidney, and lungs from acute supraceliac abdominal aorta ischemia/reperfusion injury in the rat model.

Indexed as

Aorta, AbdominalOxidative StressAnimalsDisease Models, AnimalInjections, IntraperitonealMaleProtective AgentsRatsRats, WistarReperfusion InjurySilymarinProtective AgentsSilymarin

Identifiers

PMID28076620
PMCPMC5407144
OpenAlexW2533443551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.