Evidence map›Paper›PMID 28076485›Full record

ReviewArquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

GLP-2: A POORLY UNDERSTOOD MEDIATOR ENROLLED IN VARIOUS BARIATRIC/METABOLIC SURGERY-RELATED PATHOPHYSIOLOGIC MECHANISMS.

Everton Cazzo, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Bruno Geloneze, José Carlos Pareja, Elinton Adami Chaim, Daniéla Oliveira Magro

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. WEIGHT LOSS COMPARISON AFTER SLEEVE AND ROUX-EN-Y GASTRIC BYPASS: SYSTEMATIC REVIEW.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2019
    Pooled it
  2. MINI-GASTRIC BYPASS: DESCRIPTION OF THE TECHNIQUE AND PRELIMINARY RESULTS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
    Trial
  3. Glycemic Control in Obese Type 2 Diabetic Patients Treated with Laparoscopic Sleeve Gastrectomy and Transit Bipartition.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  4. Review
  5. Review
  6. GLP-2 regulation of intestinal lipid handling.Frontiers in physiology · 2024
    Review
  7. Review
  8. Article
  9. Bile acids and metabolic surgery.Liver research (Beijing, China) · 2021
    Review
  10. Article
  11. PET-CT reveals increased intestinal glucose uptake after gastric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2019
    Article
  12. Article
  13. Article
  14. QUALITY OF LIFE AFTER VERTICAL GASTRECTOMY EVALUATED BY THE BAROS QUESTIONNAIRE.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Everton CazzoDepartment of Surgery.
Martinho Antonio GesticDepartment of Surgery.
Murillo Pimentel UtriniDepartment of Surgery.
Felipe David Mendonça ChaimDepartment of Surgery.
Bruno GelonezeResearch Laboratory in Metabology and Diabetes (Limed), State University of Campinas - Unicamp, Campinas, SP, Brazil.
José Carlos ParejaDepartment of Surgery.
Elinton Adami ChaimDepartment of Surgery.
Daniéla Oliveira MagroDepartment of Surgery.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Glucagon-like peptide-2 (GLP-2) is a gastrointestinal hormone whose effects are predominantly trophic on the intestinal mucosa. Aim: Critically evaluate the current literature on the influence of bariatric/metabolic surgery on the levels of GLP-2 and its potential clinical implications. Methods: Narrative review through online research on the databases Medline and Lilacs. There were six prospective human studies, two cross-sectional human studies, and three experimental animal studies selected. Results: There is evidence demonstrating significant increase in the levels of GLP-2 following gastric bypass, Scopinaro operation, and sleeve gastrectomy. There are no differences between gastric bypass and sleeve gastrectomy in regards to the increase in the GLP-2 levels. There is no correlation between the postoperative levels of GLP-2 and the occurrence of adequate or insufficient postoperative weight loss. Conclusion: GLP-2 plays significant roles on the regulation of nutrient absorption, permeability of gut mucosa, control of bone resorption, and regulation of satiety. The overall impact of these effects potentially exerts a significant adaptive or compensatory effect within the context of varied bariatric surgical techniques.

Indexed as

Bariatric SurgeryGastric BypassGlucagon-Like Peptide 2HumansPostoperative ComplicationsGlucagon-Like Peptide 2

Identifiers

PMID28076485
PMCPMC5225870
OpenAlexW2571002330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.