ArticlePloS one2017
A MRI-Compatible Combined Mechanical Loading and MR Elastography Setup to Study Deformation-Induced Skeletal Muscle Damage in Rats.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterizing Musculoskeletal Tissue Mechanics Based on Shear Wave Propagation: A Systematic Review of Current Methods and Reported Measurements.Annals of biomedical engineering · 2022Pooled it
- Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection.Immunity, inflammation and disease · 2026Review
- Understanding occipital pressure sores in UK military casualties: a pilot study in healthy military personnel.BMJ military health · 2024Article
- Compositional and Functional MRI of Skeletal Muscle: A Review.Journal of magnetic resonance imaging : JMRI · 2024Review
- An in vivo model for overloading-induced soft tissue injury.Scientific reports · 2022Article
- Changes in Tissue Composition and Load Response After Transtibial Amputation Indicate Biomechanical Adaptation.Annals of biomedical engineering · 2021Observational
- Exploring the role of transtibial prosthetic use in deep tissue injury development: a scoping review.BMC biomedical engineering · 2020Article
- Magnetic resonance elastography of skeletal muscle deep tissue injury.NMR in biomedicine · 2019Article
- Development of a novel multiphysical approach for the characterization of mechanical properties of musculotendinous tissues.Scientific reports · 2019Article
- Contemporary image-based methods for measuring passive mechanical properties of skeletal muscles in vivo.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Technologies to monitor the health of loaded skin tissues.Biomedical engineering online · 2018Review
- Exploration of New Contrasts, Targets, and MR Imaging and Spectroscopy Techniques for Neuromuscular Disease - A Workshop Report of Working Group 3 of the Biomedicine and Molecular Biosciences COST Action BM1304 MYO-MRI.Journal of neuromuscular diseasesArticle
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deformation of skeletal muscle in the proximity of bony structures may lead to deep tissue injury category of pressure ulcers. Changes in mechanical properties have been proposed as a risk factor in the development of deep tissue injury and may be useful as a diagnostic tool for early detection. MRE allows for the estimation of mechanical properties of soft tissue through analysis of shear wave data. The shear waves originate from vibrations induced by an external actuator placed on the tissue surface. In this study a combined Magnetic Resonance (MR) compatible indentation and MR Elastography (MRE) setup is presented to study mechanical properties associated with deep tissue injury in rats. The proposed setup allows for MRE investigations combined with damage-inducing large strain indentation of the Tibialis Anterior muscle in the rat hind leg inside a small animal MR scanner. An alginate cast allowed proper fixation of the animal leg with anatomical perfect fit, provided boundary condition information for FEA and provided good susceptibility matching. MR Elastography data could be recorded for the Tibialis Anterior muscle prior to, during, and after indentation. A decaying shear wave with an average amplitude of approximately 2 μm propagated in the whole muscle. MRE elastograms representing local tissue shear storage modulus Gd showed significant increased mean values due to damage-inducing indentation (from 4.2 ± 0.1 kPa before to 5.1 ± 0.6 kPa after, p<0.05). The proposed setup enables controlled deformation under MRI-guidance, monitoring of the wound development by MRI, and quantification of tissue mechanical properties by MRE. We expect that improved knowledge of changes in soft tissue mechanical properties due to deep tissue injury, will provide new insights in the etiology of deep tissue injuries, skeletal muscle damage and other related muscle pathologies.
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