Evidence map›Paper›PMID 28076277›Full record

ArticleJournal of insect science (Online)2016

The Combined Effect of Methyl- and Ethyl-Paraben on Lifespan and Preadult Development Period of Drosophila melanogaster (Diptera: Drosophilidae).

Qi Chen, Chenguang Pan, Yajuan Li, Min Zhang, Wei Gu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of insect science (Online), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 18 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qi ChenCollege of Life Sciences, Shaanxi Normal University, No. 620, West Chang'an Avenue, Chang'an District, Xi'an 710119, China (chenqi@snnu.edu.cn; panchenguang@snnu.edu.cn; 503619890@qq.com; zhangmin451@snnu.edu.cn) and.
Chenguang PanCollege of Life Sciences, Shaanxi Normal University, No. 620, West Chang'an Avenue, Chang'an District, Xi'an 710119, China (chenqi@snnu.edu.cn; panchenguang@snnu.edu.cn; 503619890@qq.com; zhangmin451@snnu.edu.cn) and.
Yajuan LiCollege of Life Sciences, Shaanxi Normal University, No. 620, West Chang'an Avenue, Chang'an District, Xi'an 710119, China (chenqi@snnu.edu.cn; panchenguang@snnu.edu.cn; 503619890@qq.com; zhangmin451@snnu.edu.cn) and.
Min ZhangCollege of Life Sciences, Shaanxi Normal University, No. 620, West Chang'an Avenue, Chang'an District, Xi'an 710119, China (chenqi@snnu.edu.cn; panchenguang@snnu.edu.cn; 503619890@qq.com; zhangmin451@snnu.edu.cn) and.
Wei GuCollege of Life Sciences, Shaanxi Normal University, No. 620, West Chang'an Avenue, Chang'an District, Xi'an 710119, China (chenqi@snnu.edu.cn; panchenguang@snnu.edu.cn; 503619890@qq.com; zhangmin451@snnu.edu.cn) and weigu@snnu.edu.cn.
Shaanxi Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parabens are widely used as preservative substances in foods, pharmaceuticals, industrial products, and cosmetics. But several studies have cautioned that parabens have estrogenic or endocrine-disrupting properties. Drosophila melanogaster is an ideal model in vivo to detect the toxic effects of chemistry. The study was designed to assess the potential additive toxic effects of methylparaben (MP) and ethylparaben (EP) mixture (MP + EP) on lifespan and preadult development period in D. melanogaster The data revealed that the MP + EP can reduce the longevity of flies compared with the control group, consistent with a significant reduction in malondialdehyde levels and an increase in superoxide dismutase activities. Furthermore, MP + EP may have a greater toxic effect on longevity of flies than separate using with the same concentration. Additionally, parabens had a nonmonotonic dose-response effect on D. melanogaster preadult development period, showing that MP + EP delayed preadult development period compared with control group while individual MP or EP significantly shortened (P < 0.01) at low concentration (300 mg/l). In conclusion, MP + EP had the potential additive toxicity on lifespan and preadult development period for D. melanogaster.

Indexed as

AnimalsDrosophila melanogasterFood PreservativesLongevityParabensPreservatives, Pharmaceuticalethyl-p-hydroxybenzoateFood PreservativesmethylparabenParabensPreservatives, Pharmaceuticaldevelopment periodDrosophila melanogasterethylparabenlifespanmethylparaben

Identifiers

PMID28076277
PMCPMC5778983
OpenAlexW2270720246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.