SynthesisAmerican journal of public health2017
Transgender Population Size in the United States: a Meta-Regression of Population-Based Probability Samples.
Synthesis in American journal of public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 294 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of the Effects of Testosterone and Estrogen on Eating Behavior, Metabolism, Energy Balance and Cardiovascular System in Transsexual Patients Undergoing Cross-sex Hormone Therapy
Androgen Effects on the Reproductive Neuroendocrine Axis
A Pilot Study to Investigate the Use of the Plexaa Preconditioning Device (BLOOM43) for Gender Affirming Mastectomy - a Prospective Cohort Study
Androgen Effects on the Reproductive Neuroendocrine Axis, 2025 Version
Who cites it
294 citing papers in PubMed, 7 syntheses or guidelines pooled it, 790 citations in OpenAlex.
- Mapping the cardiovascular burden in transgender individuals: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- A Systematic Review of Interventions for Young Men Who Have Sex With Men and Young Transgender Women Living with HIV.AIDS and behavior · 2024Pooled it
- Health status of transgender people globally: A systematic review of research on disease burden and correlates.PloS one · 2024Pooled it
- Demographic recruitment bias of adults in United States randomized clinical trials by disease categories between 2008 to 2019: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Barriers and Facilitators to HIV Pre-Exposure Prophylaxis Uptake, Adherence, and Persistence Among Transgender Populations in the United States: A Systematic Review.AIDS patient care and STDs · 2022Pooled it
- A systematic review of sociodemographic reporting and representation in eating disorder psychotherapy treatment trials in the United States.The International journal of eating disorders · 2022Pooled it
- HIV care outcomes among transgender persons with HIV infection in the United States, 2006-2021.AIDS (London, England) · 2022Pooled it
- Effect of a Brief Social Contact Video on Transphobia and Depression-Related Stigma Among Adolescents: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Detransition, Posttraumatic Stress Disorder, and Moral Injury.Archives of sexual behavior · 2026Article
- PrEP and PEP: awareness, use, and preferences among Latina immigrant transgender women in the Washington DC metropolitan area.AIDS care · 2026Article
- Laparoscopic-assisted versus conventional vaginal hysterectomy for gender-affirming surgery in female-to-male transgender men.Journal of the Chinese Medical Association : JCMA · 2026Article
- Navigating sexual health, fertility, and adult wellness in individuals with Duchenne muscular dystrophy: Current standards of care and future directions.Journal of neuromuscular diseases · 2026Review
- Intraoperative complications during gender-affirming laparoscopic hysterectomy in transgender men receiving testosterone: a case series.BMC surgery · 2026Article
- Article
- Single cell RNA-sequencing reveals that testosterone reduces estrogen signaling in the healthy human mammary gland.Journal of mammary gland biology and neoplasia · 2026Article
- Heart rate variability in transgender people receiving Gender-Affirming hormone therapy.Endocrine · 2026Article
- Effect of Testosterone Therapy on Cytochrome P450 3A and P-Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults.Pharmacotherapy · 2026Article
- Checking assumptions: advancing the analysis of sex and gender in health sciences.Biology of sex differences · 2026Review
- Single cell RNA-sequencing reveals an association between testosterone treatment and reduced hormone signaling in the human mammary gland.bioRxiv : the preprint server for biology · 2026Article
- Post-COVID fatigue disproportionately affects women: evidence from the DEFEAT Corona cohort.Frontiers in public health · 2026Article
234 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundTransgender individuals have a gender identity that differs from the sex they were assigned at birth. The population size of transgender individuals in the United States is not well-known, in part because official records, including the US Census, do not include data on gender identity. Population surveys today more often collect transgender-inclusive gender-identity data, and secular trends in culture and the media have created a somewhat more favorable environment for transgender people.
objectivesTo estimate the current population size of transgender individuals in the United States and evaluate any trend over time. SEARCH
methodsIn June and July 2016, we searched PubMed, Cumulative Index to Nursing and Allied Health Literature, and Web of Science for national surveys, as well as "gray" literature, through an Internet search. We limited the search to 2006 through 2016. SELECTION CRITERIA: We selected population-based surveys that used probability sampling and included self-reported transgender-identity data. DATA COLLECTION AND ANALYSIS: We used random-effects meta-analysis to pool eligible surveys and used meta-regression to address our hypothesis that the transgender population size estimate would increase over time. We used subsample and leave-one-out analysis to assess for bias. MAIN
resultsOur meta-regression model, based on 12 surveys covering 2007 to 2015, explained 62.5% of model heterogeneity, with a significant effect for each unit increase in survey year (F = 17.122; df = 1,10; b = 0.026%; P = .002). Extrapolating these results to 2016 suggested a current US population size of 390 adults per 100 000, or almost 1 million adults nationally. This estimate may be more indicative for younger adults, who represented more than 50% of the respondents in our analysis. AUTHORS'
conclusionsFuture national surveys are likely to observe higher numbers of transgender people. The large variety in questions used to ask about transgender identity may account for residual heterogeneity in our models. Public health implications. Under- or nonrepresentation of transgender individuals in population surveys is a barrier to understanding social determinants and health disparities faced by this population. We recommend using standardized questions to identify respondents with transgender and nonbinary gender identities, which will allow a more accurate population size estimate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.