SynthesisBiochemistry and cell biology = Biochimie et biologie cellulaire2017
Factors affecting lactoferrin concentration in human milk: how much do we know?
Synthesis in Biochemistry and cell biology = Biochimie et biologie cellulaire, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Determinants of human milk lactoferrin concentrations in rural Bangladesh.PLOS global public health · 2026Article
- Breastfeeding and infant gut microbiota: influence of bioactive components.Gut microbes · 2025Review
- Longitudinal changes in human milk lactoferrin during the first year: a prospective cohort study.Pediatric research · 2025Article
- Review
- Selected Protective Mechanisms of Human Milk Against Intestinal Protozoal Infections in Infants.Current issues in molecular biology · 2025Review
- Lactoferrin and SIgA Concentrations in Human Milk of SARS-CoV-Infected Mothers-Polish Cohort Study.Nutrients · 2025Article
- New latex agglutination assay for the determination of lactoferrin in human milk.International breastfeeding journal · 2024Article
- High hydrostatic pressure is similar to Holder pasteurization in preserving donor milk antimicrobial activity.Pediatric research · 2024Article
- Factors affecting total protein and lactoferrin in human milk.Scientific reports · 2023Article
- Therapeutic uses and applications of bovine lactoferrin in aquatic animal medicine: an overview.Veterinary research communications · 2023Review
- Secretory carcinoma of the salivary gland is rich in lactoferrin: a possible lactational-like differentiation?European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Endotoxin content in neonatal formulas, fortification, and lactoferrin products: association with outcomes and guidance on acceptable limits.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle.Animals : an open access journal from MDPI · 2023Review
- Human milk lactoferrin variation in relation to maternal inflammation and iron deficiency in northern Kenya.American journal of human biology : the official journal of the Human Biology Council · 2022Article
- Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are associated with linear growth and biomarkers of environmental enteric dysfunction (EED) in Bangladeshi children.Scientific reports · 2022Article
- Review
- MicroRNA profiling of gastric content from breast-fed and formula-fed infants to estimate last feeding: a pilot study.International journal of legal medicine · 2020Article
- Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life.Nutrients · 2020Review
- Review
- Lactoferrin in Human Milk of Prolonged Lactation.Nutrients · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Lactoferrin (LF) is a breast milk glycoprotein with antimicrobial and anti-inflammatory effects. Its beneficial properties in infants, especially in those born preterm, are currently being studied in clinical trials. However, the maternal and nursing infant factors that may affect LF concentration in breast milk are still not clear. We conducted a systematic review to investigate the factors that may affect the concentration of LF in breast milk. We used a 2-step approach to identify the eligible studies according to inclusion/exclusion criteria, and to determine which studies would be considered. We included 70 qualified articles from 29 countries with publication dates ranging from 1976 to 2015. We described the correlation between LF concentration in breast milk and lactation stage; 10 maternal factors, such as race, parity, among others; and 2 infant factors: infections and prematurity. Colostrum has the highest LF levels, but they decrease with days postpartum. No other factor has been consistently associated with LF concentration. A major limitation of the majority of the published studies is the small sample size and the different methods used to measure LF concentration. Therefore, there is a need for large, multicenter studies with standardized study design, sample collection, and LF measurement methods to identify clinically significant factors associated with LF expression in breast milk, which will help promote exclusive breastfeeding in preterm infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.