The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?

Susan B Brogly, Kelley Saia, Sonia Hernández-Diaz, Martha Werler, Paola Sebastiani

Abstract readComment

In one paragraph

Article in Addiction (Abingdon, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Opioid, methamphetamine, and polysubstance use: perinatal outcomes for the mother and infant.Frontiers in pediatrics · 2023
Review
Naltrexone Treatment for Pregnant Women With Opioid Use Disorder Compared With Matched Buprenorphine Control Subjects.Clinical therapeutics · 2019
Article
Examination of Hospital, Maternal, and Infant Characteristics Associated with Breastfeeding Initiation and Continuation Among Opioid-Exposed Mother-Infant Dyads.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2018
Article
Medication for Addiction Treatment and Postpartum Health Care Utilization Among Pregnant Persons With Opioid Use Disorder.Journal of addiction medicine
Article

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Susan B BroglyDepartment of Surgery, Queens University, Kingston, Canada.

Kelley SaiaObstetrics and Gynecology, Boston Medical Center, Boston, MA, USA.

Sonia Hernández-DiazDepartment of Epidemiology, Harvard University T H Chan School of Public Health, Boston, MA, USA.

Martha WerlerDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Paola SebastianiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Funding

Comparative Safety of Buprenorphine vs. Methadone in PregnancyR21HD081271 · NICHD · QUEEN'S UNIVERSITY AT KINGSTON · PI BROGLY, SUSAN B · 2014 to 2015

$410k

NICHD NIH HHS R21 HD081271

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BuprenorphineMethadoneFemaleHumansNeonatal Abstinence SyndromeOpiate Substitution TreatmentOpioid-Related DisordersPregnancyPregnancy ComplicationsBuprenorphineMethadoneBirth outcomesbuprenorphineinfantsmethadoneneonatal abstinence syndromepregnancy

Identifiers

PMID28075537

DOI10.1111/add.13551

PMCPMC5571444

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.