Evidence map›Paper›PMID 28075522›Full record

ArticleCancer science2017

Crucial role of carbonic anhydrase IX in tumorigenicity of xenotransplanted adult T-cell leukemia-derived cells.

Kentaro Nasu, Kazunori Yamaguchi, Tomoka Takanashi, Keiichi Tamai, Ikuro Sato, Shoji Ine, Osamu Sasaki, Kennichi Satoh, Nobuyuki Tanaka, Yuetsu Tanaka and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Gene expression of carbonic anhydrase 9 (CA9) inJournal of medicine and life · 2022
    Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kentaro NasuDivision of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
Kazunori YamaguchiDivision of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
Tomoka TakanashiDivision of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
Keiichi TamaiDepartment of Cancer Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ikuro SatoDepartment of Cancer Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shoji IneDivision of Hematology, Miyagi Cancer Center Research Institute, Natori, Japan.
Osamu SasakiDivision of Hematology, Miyagi Cancer Center Research Institute, Natori, Japan.
Kennichi SatohDepartment of Cancer Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
Nobuyuki TanakaDepartment of Cancer Science, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yuetsu TanakaDepartment of Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Takuya FukushimaLaboratory of Hemato-Immunology, Faculty of Medicine, School of Health Sciences, University of the Ryukyus, Okinawa, Japan.
Hideo HarigaeDepartment of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kazuo SugamuraDivision of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
Miyagi Prefectural Hospital Organization · JPTohoku University · JPUniversity of the Ryukyus · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbonic anhydrase IX (CA9) is a membrane-associated carbonic anhydrase that regulates cellular pH, is upregulated in various solid tumors, and is considered to be a therapeutic target. Here, we describe the essential role of CA9 in the tumorigenicity of cells derived from human adult T-cell leukemia/lymphoma (ATL). We previously established the highly tumorigenic ST1-N6 subline from the ATL-derived ST1 cell line by serial xenotransplantation in NOG mice. In the present study, we first show that CA9 expression is strongly enhanced in ST1-N6 cells. We then sorted ST1 cells by high or low CA9 expression and established ST1-CA9

Indexed as

AnimalsAntigens, NeoplasmCarbonic Anhydrase IXCatalytic DomainCell Line, TumorCell Transformation, NeoplasticHumansLeukemia-Lymphoma, Adult T-CellLymph NodesMiceMice, Inbred NODMice, SCIDNeoplasm TransplantationRNA InterferenceRNA, Small InterferingTransplantation, HeterologousAntigens, NeoplasmCA9 protein, humanCarbonic Anhydrase IXRNA, Small InterferingAdult T-cell leukemia/lymphomacarbonic anhydrase IXhuman T-cell leukemia virus type 1tumorigenicityxenotransplantation

Identifiers

PMID28075522
PMCPMC5378273
OpenAlexW2579672450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.