ReviewInternational journal of molecular sciences2017
The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles.
Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 316 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
316 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,093 citations in OpenAlex.
- Markers of the ageing macrophage: a systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Mitochondria-Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential.Advanced healthcare materials · 2026Review
- The role of stem cells in the pharmacological assessment of nanoparticles.Journal of pharmaceutical analysis · 2026Review
- Redox-modulating metallic nanoparticles: mechanistic insights into pharmacological activity and cellular therapeutics.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Green synthesized silver nanoparticles from Artocarpus hirsutus flower extract induced cytotoxicity and apoptosis in HT29 colon cancer cells.Discover nano · 2026Article
- Biogenic Silver Nanoparticles Synthesised Using Staphylococcus saprophyticus Cell-Free Supernatant Exhibit Potent Antimicrobial Activities via Oxidative Stress.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Comparative evaluation of bulk and nano-formulated calcium, phosphorus, and potassium fertilizers in improving salinity tolerance of faba bean.BMC plant biology · 2026Article
- Prospects and challenges in intracellular delivery of therapeutic proteins.Pharmacological reports : PR · 2026Review
- Broccoli triggers the hemocompatibility of green nanoparticles.Discover nano · 2026Article
- Antimicrobial Properties of Ti- and Zr-Based Nanotextured Thin Film Metallic Glasses AgainstBiomolecules · 2026Article
- Bioengineered Silver Nanoparticles: Next-Generation Biogenic Synthesis Strategies for Precision Biomedical Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Research on Silver-Based Wound Dressing: An Ontological Analysis.Antibiotics (Basel, Switzerland) · 2026Review
- Calcium Phosphate Nanostructured Biocomposites with Applications in Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Review
- Optimized green zinc oxide/chitosan/amoxicillin nanocomposite against Pseudomonas aeruginosa.Applied microbiology and biotechnology · 2026Article
- Antimicrobial, antibiofilm, DNA binding, and antioxidant activities of green synthesized zinc oxide nanoparticles using the wild mushroom Lepista sordida (Schumach) singer EGDA2.Microbial cell factories · 2026Article
- Harnessing Antioxidants for Abiotic Stress Management: Mechanistic Insights and Prospects for Sustainable Agriculture.Antioxidants (Basel, Switzerland) · 2026Review
- Tetramethylbenzidine loaded PVA nanofibers strip for visual detection of hydrogen peroxide via CuJournal of biological engineering · 2026Article
- Eco-friendly fabrication of silver nanoparticles fromRSC advances · 2026Article
- Phytosynthesis of Selenium Nanoparticles fromAnti-cancer agents in medicinal chemistry · 2026Article
- Biodiversity Buffers Phytoplankton Biomass Production Against Nanoparticle Pollution Through Increased Facilitation.Ecology letters · 2025Article
256 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation. In this review, we briefly explained NP classes and their biomedical applications and describe the sources and roles of ROS in NP-related biological functions in vitro and in vivo. Furthermore, we also described the roles of metal NP-induced ROS generation in stem cell biology. Although the roles of ROS in metallic NP-related biological functions requires further investigation, modulation and characterization of metallic NP-induced ROS production are promising in the application of metallic NPs in the areas of regenerative medicine and medical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.