ArticleeLife2017
Transformation of spatiotemporal dynamics in the macaque vestibular system from otolith afferents to cortex.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Mechanistic research on the vestibular-hippocampal pathway in neurodegenerative diseases: an integrative perspective from molecular to behavioral levels.Frontiers in neuroscience · 2026Review
- Multisensory coding of self-motion and its contribution to navigation.Nature reviews. Neuroscience · 2025Review
- Graviception Uncertainty, Spatial Anxiety, and Derealization in Patients with Persistent Postural-Perceptual Dizziness.Journal of clinical medicine · 2024Article
- Protocol for behavioral and neural recording in macaques during a novelty detection task.STAR protocols · 2024Article
- From Multisensory Integration to Multisensory Decision-Making.Advances in experimental medicine and biology · 2024Review
- Tilt in Place Microscopy: a Simple, Low-Cost Solution to Image Neural Responses to Body Rotations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortical Mechanisms of Multisensory Linear Self-motion Perception.Neuroscience bulletin · 2023Review
- Temporal and spatial properties of vestibular signals for perception of self-motion.Frontiers in neurology · 2023Review
- Cognitive, Systems, and Computational Neurosciences of the Self in Motion.Annual review of psychology · 2022Review
- Article
- Vestibular-Evoked Cerebral Potentials.Frontiers in neurology · 2021Review
- The role of acceleration and jerk in perception of above-threshold surge motion.Experimental brain research · 2020Article
- Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Article
- Vestibular processing during natural self-motion: implications for perception and action.Nature reviews. Neuroscience · 2019Review
- Optogenetic fMRI interrogation of brain-wide central vestibular pathways.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Vestibular System and Self-Motion.Frontiers in cellular neuroscience · 2018Review
- A unified internal model theory to resolve the paradox of active versus passive self-motion sensation.eLife · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Sensory signals undergo substantial recoding when neural activity is relayed from sensors through pre-thalamic and thalamic nuclei to cortex. To explore how temporal dynamics and directional tuning are sculpted in hierarchical vestibular circuits, we compared responses of macaque otolith afferents with neurons in the vestibular and cerebellar nuclei, as well as five cortical areas, to identical three-dimensional translational motion. We demonstrate a remarkable spatio-temporal transformation: otolith afferents carry spatially aligned cosine-tuned translational acceleration and jerk signals. In contrast, brainstem and cerebellar neurons exhibit non-linear, mixed selectivity for translational velocity, acceleration, jerk and position. Furthermore, these components often show dissimilar spatial tuning. Moderate further transformation of translation signals occurs in the cortex, such that similar spatio-temporal properties are found in multiple cortical areas. These results suggest that the first synapse represents a key processing element in vestibular pathways, robustly shaping how self-motion is represented in central vestibular circuits and cortical areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.