Trial reportClinical transplantation2017
Abdominal lean muscle is associated with lower mortality among kidney waitlist candidates.
Trial report in Clinical transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Pooled it
- Automated Muscle Measurement on Chest CT Predicts All-Cause Mortality in Older Adults From the National Lung Screening Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Comparison of Multiple Frailty Scoring Metrics in Renal Transplant Candidates: A Large Single-center Cohort Study.Transplantation direct · 2026Article
- Associations of Fecal Microbiota with Ectopic Fat in African Caribbean Men.Microorganisms · 2024Article
- Abdominal computed tomography measurements of body composition and waitlist mortality in kidney transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Associations of Sarcopenia and Body Composition Measures With Mortality After Transcatheter Aortic Valve Replacement.Circulation. Cardiovascular interventions · 2024Article
- Thigh and Calf Myosteatosis are Strongly Associated with Muscle and Physical Function in African Caribbean Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Sarcopenia of kidney transplant recipients as a predictive marker for reduced graft function and graft survival after kidney transplantation.Langenbeck's archives of surgery · 2023Article
- Crosstalk between bone and muscle in chronic kidney disease.Frontiers in endocrinology · 2023Review
- Replacing sedentary time with light activity was associated with less adiposity across several depots in African ancestry men.Obesity (Silver Spring, Md.) · 2022Article
- Reference values for MRI-derived psoas and paraspinal muscles and macroscopic fat infiltrations in paraspinal muscles in children.Journal of cachexia, sarcopenia and muscle · 2022Article
- Body Composition by Computed Tomography vs Dual-Energy X-ray Absorptiometry: Long-Term Prediction of All-Cause Mortality in the Health ABC Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Obesity Management in Kidney Transplant Candidates: Current Paradigms and Gaps in Knowledge.Advances in chronic kidney disease · 2021Review
- Sarcopenia and Frailty: Challenges in Mainstream Nephrology Practice.Kidney international reports · 2021Review
- Surgical complications risk in obese and overweight recipients for kidney transplantation: a predictive morphometric model based on sarcopenia and vessel-to-skin distance.World journal of urology · 2021Article
- Sarcopenia in Children With End-Stage Liver Disease on the Transplant Waiting List.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2021Article
- Systematic review and meta-analysis of lean mass and mortality: Rationale and study description.Osteoporosis and sarcopenia · 2021Article
- Muscle area and density and risk of all-cause mortality: The Multi-Ethnic Study of Atherosclerosis.Metabolism: clinical and experimental · 2020Article
- Hepatic and Skeletal Muscle Adiposity Are Associated with Diabetes Independent of Visceral Adiposity in Nonobese African-Caribbean Men.Metabolic syndrome and related disorders · 2020Article
- An overview of frailty in kidney transplantation: measurement, management and future considerations.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Morphometric assessments, such as muscle density and body fat distribution, have emerged as strong predictors of cardiovascular risk and postoperative morbidity and mortality. To date, no study has examined morphometric mortality risk prediction among kidney transplant (KT) candidates. KT candidates, waitlisted 2008-2009, were identified (n=96) and followed to the earliest of transplant, death, or administrative end of study. Morphometric measures, including abdominal adipose tissue, paraspinous and psoas muscle composition, and aortic calcification, were measured from CTs. Risk of waitlist mortality was examined using Cox proportional hazard regression. On adjusted analyses, radiologic measures remained independently and significantly associated with lower waitlist mortality; the addition of radiologic measures significantly improved model predictive ability over models containing traditional risk factors alone (net reclassification index: 0.56, 95% CI: 0.31-0.75). Higher psoas muscle attenuation (indicative of leaner muscle) was associated with decreased risk of death (aHR: 0.93, 95% CI: 0.91-0.96, P<.001), and for each unit increase in lean paraspinous volume, there was an associated 2% decreased risk for death (aHR: 0.98, 95% CI: 0.96-0.99, P=.03). Radiologic measures of lean muscle mass, such as psoas muscle attenuation and paraspinous lean volume, may improve waitlist mortality risk prediction and candidate selection.
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