ArticleAlcoholism, clinical and experimental research2017
Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol.
Article in Alcoholism, clinical and experimental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Cognitive Processes Influencing Written Sentence Construction in School-Aged Children With Prenatal Alcohol Exposure.Psychology in the schools · 2025Article
- Fetal Alcohol Spectrum Disorders.Current topics in behavioral neurosciences · 2025Review
- Article
- Altered markers of brain metabolism and excitability are associated with executive functioning in young children exposed to alcohol in utero.Metabolic brain disease · 2024Article
- Sex-specific alterations in cognitive control following moderate prenatal alcohol exposure and transient systemic hypoxia ischemia in the rat.Alcohol, clinical & experimental research · 2024Article
- Perinatal influences on academic achievement and the developing brain: a scoping systematic review.Frontiers in psychology · 2024Article
- Functional connectivity of cognition-related brain networks in adults with fetal alcohol syndrome.BMC medicine · 2023Article
- Examining the effects of prenatal alcohol exposure on performance of the sustained attention to response task in children with an FASD.Human brain mapping · 2023Article
- Transgenerational Effects of Prenatal Ethanol Exposure in Prepubescent Mice.Frontiers in cell and developmental biology · 2022Article
- Early delay of gratification predicts later inhibitory control and academic performance in children with prenatal alcohol exposure.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Article
- Article
- Fetal Alcohol Spectrum Disorders: A Review of the Neurobehavioral Deficits Associated With Prenatal Alcohol Exposure.Alcoholism, clinical and experimental research · 2019Review
- Neural Switch Asymmetry in Feature-Based Auditory Attention Tasks.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- Prenatal Exposure to Alcohol Induces Functional and Structural Plasticity in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum.Alcoholism, clinical and experimental research · 2018Article
- Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder.PloS one · 2018Article
- Preliminary Findings that a Targeted Intervention Leads to Altered Brain Function in Children with Fetal Alcohol Spectrum Disorder.Brain sciences · 2017Article
- Ethanol (E) Impairs Fetal Brain GSH Homeostasis by Inhibiting Excitatory Amino-Acid Carrier 1 (EAAC1)-Mediated Cysteine Transport.International journal of molecular sciences · 2017Article
- Choline and Working Memory Training Improve Cognitive Deficits Caused by Prenatal Exposure to Ethanol.Nutrients · 2017Article
- The Use of Functional Near-Infrared Spectroscopy to Differentiate Alcohol-Related Neurodevelopmental Impairment.Developmental neuropsychologyArticle
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundResponse inhibition is a distinct aspect of executive function that is frequently impaired in children with fetal alcohol spectrum disorders (FASD). We used a Go/NoGo (GNG) task in a functional MRI protocol to investigate differential activation of brain regions in the response inhibition network in children diagnosed with full or partial fetal alcohol syndrome (FAS/PFAS), compared with healthy controls.
methodsA rapid, event-related task with 120 Go and 60 NoGo trials was used to study children aged 8 to 12 years-8 with FAS/PFAS, 17 controls. Letters were projected sequentially, with Go and NoGo trials randomly interspersed across the task. BOLD signal in the whole brain was contrasted for the correct NoGo minus correct Go trials between the FAS/PFAS and control groups.
resultsCompared to the FAS/PFAS group, controls showed greater activation of the inferior frontal and anterior cingulate network linked to response inhibition in typically developing children. By contrast, the FAS/PFAS group showed greater BOLD response in dorsolateral prefrontal cortex and other middle prefrontal regions, suggesting compensation for inefficient function of pathways that normally mediate inhibitory processing. All group differences were significant after control for potential confounding variables. None of the effects of prenatal alcohol exposure on activation of the regions associated with response inhibition were attributable to the effects of this exposure on IQ.
conclusionsThis is the first FASD GNG study in which all participants in the exposed group met criteria for a diagnosis of full FAS or PFAS. Although FASD is frequently comorbid with attention deficit hyperactivity disorder, the pattern of brain activation seen in these disorders differs, suggesting that different neural pathways mediate response inhibition in FASD and that different interventions for FASD are, therefore, warranted.
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