Trial reportScientific reports2017
Metabotyping Patients' Journeys Reveals Early Predisposition to Lung Injury after Cardiac Surgery.
Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Perioperative Blood Biomarkers of Infectious and Non-Infectious Postoperative Pulmonary Complications: A Narrative Review.Journal of clinical medicine · 2026Review
- Prediction of acute lung injury/acute respiratory distress syndrome after cardiopulmonary bypass in infants by monitoring femoral oxygen saturation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Hyperkalemic or Low Potassium Cardioplegia Protects against Reduction of Energy Metabolism by Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics.Metabolism open · 2021Article
- Identifying metabolic alterations in newly diagnosed small cell lung cancer patients.Metabolism open · 2021Article
- Metabolic changes during carbon monoxide poisoning: An experimental study.Journal of cellular and molecular medicine · 2021Article
- Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness.Journal of cachexia, sarcopenia and muscle · 2020Article
- Citrate NMR peak irreproducibility in blood samples after reacquisition of spectra.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Hyperoxia affects the lung tissue: A porcine histopathological and metabolite study using five hours of apneic oxygenation.Metabolism open · 2019Article
- Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Blood Electrolytes and Metabolites-A Randomized Controlled Trial.Journal of clinical medicine · 2018Article
- Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients.Metabolites · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease is the leading cause of death worldwide and patients with severe symptoms undergo cardiac surgery. Even after uncomplicated surgeries, some patients experience postoperative complications such as lung injury. We hypothesized that the procedure elicits metabolic activity that can be related to the disease progression, which is commonly observed two-three days postoperatively. More than 700 blood samples were collected from 50 patients at nine time points pre-, intra-, and postoperatively. Dramatic metabolite shifts were observed during and immediately after the intervention. Prolonged surgical stress was linked to an augmented anaerobic environment. Time series analysis showed shifts in purine-, nicotinic acid-, tyrosine-, hyaluronic acid-, ketone-, fatty acid, and lipid metabolism. A characteristic 'metabolic biosignature' was identified correlating with the risk of developing postoperative complications two days before the first clinical signs of lung injury. Hence, this study demonstrates the link between intra- and postoperative time-dependent metabolite changes and later postoperative outcome. In addition, the results indicate that metabotyping patients' journeys early, during or just after the end of surgery, may have potential impact in hospitals for the early diagnosis of postoperative lung injury, and for the monitoring of therapeutics targeting disease progression.
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