Evidence map›Paper›PMID 28074888›Full record

ReviewEuropean journal of clinical nutrition2017

A review of the carbohydrate-insulin model of obesity.

K D Hall

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in European journal of clinical nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  20. Carbohydrate-insulin model: does the conventional view of obesity reverse cause and effect?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

K D HallNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.

Funding

Modeling interactions of diet, exercise, metabolism, and weight change in humansZIADK013037 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI DARCEY, VALERIE · 2009 to 2025
$10.8M
6 · The paper itself

Abstract

The carbohydrate-insulin model of obesity theorizes that diets high in carbohydrate are particularly fattening due to their propensity to elevate insulin secretion. Insulin directs the partitioning of energy toward storage as fat in adipose tissue and away from oxidation by metabolically active tissues and purportedly results in a perceived state of cellular internal starvation. In response, hunger and appetite increases and metabolism is suppressed, thereby promoting the positive energy balance associated with the development of obesity. Several logical consequences of this carbohydrate-insulin model of obesity were recently investigated in a pair of carefully controlled inpatient feeding studies whose results failed to support key model predictions. Therefore, important aspects of carbohydrate-insulin model have been experimentally falsified suggesting that the model is too simplistic. This review describes the current state of the carbohydrate-insulin model and the implications of its recent experimental tests.

Indexed as

AdiposityBody WeightDietDietary CarbohydratesEnergy MetabolismHumansInsulinInsulin SecretionModels, BiologicalObesityDietary CarbohydratesInsulin

Identifiers

PMID28074888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.