Trial reportScientific reports2017
First objective evaluation of taste sensitivity to 6-n-propylthiouracil (PROP), a paradigm gustatory stimulus in humans.
Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- COVID-19 as a worldwide selective event and bitter taste receptor polymorphisms: An ecological correlational study.International journal of biological macromolecules · 2021Pooled it
- Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects.Molecules (Basel, Switzerland) · 2021Trial
- Time Course of Salivary Protein Responses to Cranberry-Derived Polyphenol Exposure as a Function of PROP Taster Status.Nutrients · 2020Trial
- Article
- [Development and application of gustatory evoked potentiometer].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Review
- Evaluation of Taste Perception and Olfactory Function in Adolescents in Relation to the Duration of Type 1 Diabetes.Pediatric diabetes · 2025Article
- Gene Methylation Affects Salivary Levels of the Taste Buds' Trophic Factor, Gustin Protein.Nutrients · 2024Article
- Time-frequency analysis of gustatory event related potentials (gERP) in taste disorders.Scientific reports · 2024Article
- Automated identification of the genetic variants of TAS2R38 bitter taste receptor with supervised learning.Computational and structural biotechnology journal · 2023Article
- A Simple Taste Test for Clinical Assessment of Taste and Oral Somatosensory Function-The "Seven-iTT".Life (Basel, Switzerland) · 2022Article
- Article
- The Effects of Cranberry Polyphenol Extract (CPE) Supplementation on Astringency and Flavor Perception as a Function of PROP Taster Status and Other Individual Factors.International journal of environmental research and public health · 2022Article
- Automated Classification of 6-n-Propylthiouracil Taster Status with Machine Learning.Nutrients · 2022Article
- Association Between Bitter Taste Receptor Phenotype and Clinical Outcomes Among Patients With COVID-19.JAMA network open · 2021Article
- Treatment Protocol for COVID-19 Based on T2R Phenotype.Viruses · 2021Article
- Article
- Allyl Isothiocyanate: A TAS2R38 Receptor-Dependent Immune Modulator at the Interface Between Personalized Medicine and Nutrition.Frontiers in immunology · 2021Article
- Electrophysiological Responses from the Human Tongue to the Six Taste Qualities and Their Relationships with PROP Taster Status.Nutrients · 2020Article
- Insights into smell and taste sensitivity in normal weight and overweight-obese adolescents.Physiology & behavior · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Practical and reliable methods for the objective measure of taste function are critically important for studying eating behavior and taste function impairment. Here, we present direct measures of human gustatory response to a prototypical bitter compound, 6-n-propyltiouracil (PROP), obtained by electrophysiological recordings from the tongue of subjects who were classified for taster status and genotyped for the specific receptor gene (TAS2R38), and in which taste papilla density was determined. PROP stimulation evoked negative slow potentials that represent the summated depolarization of taste cells. Depolarization amplitude and rate were correlated with papilla density and perceived bitterness, and associated with taster status and TAS2R38. Our study provides a robust and generalizable research tool for the quantitative measure of peripheral taste function, which can greatly help to resolve controversial outcomes on the PROP phenotype role in taste perception and food preferences, and be potentially useful for evaluating nutritional status and health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.