Evidence map›Paper›PMID 28074839›Full record

ArticleScientific reports2017

High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation.

Zizhong Hu, Haonan Zhang, Aghapi Mordovanakis, Yannis M Paulus, Qinghuai Liu, Xueding Wang, Xinmai Yang

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Photo-Mediated Ultrasound Therapy (PUT) for the Treatment of Deep Cutaneous Vasculature.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Ultrasound-assisted laser therapy for selective removal of melanoma cells.Experimental biology and medicine (Maywood, N.J.) · 2024
    Article
  7. Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy.JID innovations : skin science from molecules to population health · 2023
    Article
  8. Article
  9. A review on photo-mediated ultrasound therapy.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. TowardsIEEE transactions on radiation and plasma medical sciences · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zizhong HuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Haonan ZhangDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Aghapi MordovanakisDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
Yannis M PaulusDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Qinghuai LiuDepartment of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Xinmai YangBioengineering Research Center and Department of Mechanical Engineering, University of Kansas, Lawrence, KS, USA.

Funding

Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
Physiology of Inflammatory Arthritis in High ResolutionR01AR060350 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, XUEDING · 2011 to 2021
$6.0M
Photonic Nanosonophores for Functional and Structural ImagingR01CA186769 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOPELMAN, RAOUL, WANG, XUEDING · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA186769NEI NIH HHS K12 EY022299NIAMS NIH HHS R01 AR060350
6 · The paper itself

Abstract

Antivascular therapy represents a proven strategy to treat angiogenesis. By applying synchronized ultrasound bursts and nanosecond laser irradiation, we developed a novel, selective, non-invasive, localized antivascular method, termed photo-mediated ultrasound therapy (PUT). PUT takes advantage of the high native optical contrast among biological tissues and can treat microvessels without causing collateral damage to the surrounding tissue. In a chicken yolk sac membrane model, under the same ultrasound parameters (1 MHz at 0.45 MPa and 10 Hz with 10% duty cycle), PUT with 4 mJ/cm

Indexed as

Low-Level Light TherapyUltrasonic TherapyAnimalsBloodChickensEarHumansNeovascularization, PathologicRabbitsYolk Sac

Identifiers

PMID28074839
PMCPMC5225605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.