ArticleMagnetic resonance in medicine2017
In vivo imaging of the progression of acute lung injury using hyperpolarized [1-
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Advances in noninvasive imaging for detecting radiation-induced lung injury (RILI).International journal of radiation biology · 2025Review
- Cardiovascular magnetic resonance imaging for inflammatory heart diseases.Cardiovascular diagnosis and therapy · 2020Review
- Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst.Catalysis science & technology · 2020Article
- Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation.Frontiers in physiology · 2020Review
- Lessons learned in acute respiratory distress syndrome from the animal laboratory.Annals of translational medicine · 2019Review
- Detection of lung transplant rejection in a rat model using hyperpolarized [1-NMR in biomedicine · 2019Article
- Using coligands to gain mechanistic insight into iridium complexes hyperpolarized withChemical science · 2019Article
- Lung Metabolism and Inflammation during Mechanical Ventilation; An Imaging Approach.Scientific reports · 2018Article
- Novel imaging approaches for small animal models of lung disease (2017 Grover Conference series).Pulmonary circulationArticle
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo investigate pulmonary metabolic alterations during progression of acute lung injury.
methodsUsing hyperpolarized [1-
resultsThe mean lactate-to-pyruvate ratio of the injured-1 cohort was 0.15 ± 0.02 and 0.15 ± 0.03 at baseline and 1 h after the injury, and significantly increased from the baseline value 3 h after the injury to 0.23 ± 0.02 (P = 0.002). The mean lactate-to-pyruvate ratio of the injured-2 cohort decreased from 0.14 ± 0.03 at baseline to 0.08 ± 0.02 1 h after the injury and further decreased to 0.07 ± 0.02 (P = 0.08) 3 h after injury. No significant change was observed in the control group. Compliance in both injured groups decreased significantly after the injury (P < 0.01).
conclusionsOur findings suggest that in severe cases of lung injury, edema and hyperperfusion in the injured lung tissue may complicate interpretation of the pulmonary lactate-to-pyruvate ratio as a marker of inflammation. However, combining the lactate-to-pyruvate ratio with pulmonary compliance provides more insight into the progression of the injury and its severity. Magn Reson Med 78:2106-2115, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.